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Comparative Study
. 1977 May;28(2):233-40.

The relationship of defective cell-mediated immunity to visceral disease in systemic sclerosis

P Hughes, S Holt, N R Rowell, I D Allonby, K Janis, J K Dodd
Comparative Study

The relationship of defective cell-mediated immunity to visceral disease in systemic sclerosis

P Hughes et al. Clin Exp Immunol. 1977 May.

Abstract

Phytohaemagglutinin-induced lymphocyte transformation and circulating thymus-dependent (T) lymphocyte numbers were studied in twenty-eight patients with systemic sclerosis (SS), in fifty normal controls and eleven elderly controls. Patients with SS were found to have impaired lymphocyte transformation responses which showed a positive correlation with both the number of circulating T lymphocytes and the extent of visceral involvement by the disease. This defect of cell-mediated immunity could not be attributed to the effects of increasing age, corticosteroid treatment, iron and folate deficiency or inhibitory serum factors and may have pathogenetic implications for the disorder.

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