Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Jul;83(14):5165-9.
doi: 10.1073/pnas.83.14.5165.

Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus

D R Higgs, J S Wainscoat, J Flint, A V Hill, S L Thein, R D Nicholls, H Teal, H Ayyub, T E Peto, A G Falusi, et al.

Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus

D R Higgs et al. Proc Natl Acad Sci U S A. 1986 Jul.

Abstract

Extensive molecular studies have characterized 15 dimorphic and 2 multiallelic genetic markers within the human alpha-globin gene cluster. Analysis of these markers in 9 populations has shown that the alpha-globin locus is remarkably polymorphic and is therefore an ideal marker on chromosome 16 for the construction of a human genetic linkage map. The combined analysis of 9 polymorphic markers has established alpha-globin haplotypes that provide the means to study the molecular genetics and common mutants of this cluster. The novel association of a conventional restriction fragment length polymorphism haplotype and linked, hypervariable regions of DNA should allow a comparison of the rate of change of such markers.

PubMed Disclaimer

References

    1. Mol Biol Med. 1984 Jun;2(3):223-38 - PubMed
    1. Am J Hum Genet. 1985 May;37(3):571-80 - PubMed
    1. Cell. 1985 Oct;42(3):809-19 - PubMed
    1. Nucleic Acids Res. 1985 Nov 11;13(21):7569-78 - PubMed
    1. Br Med J (Clin Res Ed). 1986 Mar 29;292(6524):851-3 - PubMed

LinkOut - more resources