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Case Reports
. 2019 Feb;47(1):115-119.
doi: 10.1007/s15010-018-1201-x. Epub 2018 Aug 25.

Overdose of elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide in an HIV-1-infected subject with attempted suicide

Hortensia Álvarez  1 , Ana Mariño  2 , Nieves Valcarce  3 , Jesús García-González  4 , Helena Díaz-Cambre  5 , Josep M Llibre  6
Affiliations
Case Reports

Overdose of elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide in an HIV-1-infected subject with attempted suicide

Hortensia Álvarez et al. Infection. 2019 Feb.

Abstract

Introduction: Data are lacking regarding overdose of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (E/C/F/TAF).

Material and methods: We present the first report of suicidal attempt with E/C/F/TAF in a Human Immunodeficiency Virus-infected subject.

Results: A reversible acute renal failure with no proximal tubulopathy and neuropsychiatric issues are discussed. E/C/F/TAF withdrawal resulted in favourable renal and neuropsychiatric outcomes. The suicide attempt seemed unrelated to the integrase strand transfer inhibitor, being evenly explained within the context of stressful personal conflicts.

Conclusion: A suicidal attempt with an E/C/F/TAF overdose in an HIV-infected patient, resulted in a favourable outcome from a renal and neuropsychiatric standpoint.

Keywords: Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide; Overdose; Suicide attempt.

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References

    1. J Acquir Immune Defic Syndr. 2014 Mar 1;65(3):e118-20 - PubMed
    1. Lancet HIV. 2016 Dec;3(12):e561-e568 - PubMed
    1. Antimicrob Agents Chemother. 2015 Oct;59(10):5909-16 - PubMed
    1. Lancet Infect Dis. 2016 Jan;16(1):43-52 - PubMed
    1. J Acquir Immune Defic Syndr. 2017 Jun 1;75(2):211-218 - PubMed

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