doi: 10.1126/science.3014647.
Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoprotein
- PMID: 3014647
- DOI: 10.1126/science.3014647
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Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoprotein
Science.
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Abstract
Mammalian cell lines have been engineered to produce a secreted form of the AIDS retrovirus envelope glycoprotein. The recombinant protein has been isolated from growth-conditioned culture media and used to immunize animals. Antibodies directed against the recombinant molecule were found to react with the envelope glycoprotein produced in virus-infected cells. Furthermore, these antibodies were able to directly inactivate the AIDS retrovirus in a neutralization assay in vitro. The expression system reported here should provide sufficient quantities of the AIDS retrovirus envelope protein for biological and vaccination studies.
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