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. 1986 Jul 11;233(4760):209-12.
doi: 10.1126/science.3014647.

Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoprotein

L A Lasky, J E Groopman, C W Fennie, P M Benz, D J Capon, D J Dowbenko, G R Nakamura, W M Nunes, M E Renz, P W Berman

Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoprotein

L A Lasky et al. Science. .

Abstract

Mammalian cell lines have been engineered to produce a secreted form of the AIDS retrovirus envelope glycoprotein. The recombinant protein has been isolated from growth-conditioned culture media and used to immunize animals. Antibodies directed against the recombinant molecule were found to react with the envelope glycoprotein produced in virus-infected cells. Furthermore, these antibodies were able to directly inactivate the AIDS retrovirus in a neutralization assay in vitro. The expression system reported here should provide sufficient quantities of the AIDS retrovirus envelope protein for biological and vaccination studies.

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