Long-term outcomes of status epilepticus: A critical assessment

Abstract

We reviewed 37 studies reporting long-term outcomes after a status epilepticus (SE) episode in pediatric and adult populations. Study design, length of follow-up, outcome measures, domains investigated (mortality, SE recurrence, subsequent epilepsy, cognitive outcome, functional outcome, or quality of life), and predictors of long-term outcomes are summarized. Despite heterogeneity in the design of prior studies, overall risk of poor long-term outcome after SE is high in both children and adults. Etiology is the main determinant of outcome, and the effect of age or SE duration is often difficult to distinguish from the underlying cause. The effect of the treatment on long-term outcome after SE is still unknown.

Keywords: cognitive outcome; epilepsy; functional impairment; mortality; neurological sequelae; quality of life.

Figure 1

PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) diagram of the literature search