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Review
. 2018 Aug 14:11:4829-4835.
doi: 10.2147/OTT.S164574. eCollection 2018.

Adenosquamous carcinoma of the lung

Chenghui Li  1   2 , Hongyang Lu  2   3
Affiliations
Review

Adenosquamous carcinoma of the lung

Chenghui Li et al. Onco Targets Ther. .

Abstract

Adenosquamous carcinoma of the lung (ASC), a relatively rare subtype of non-small-cell lung cancer, is defined as a malignancy containing components of lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SCC). Although ASC has biological characteristics of ADC and SCC, it is not by any means a simple hybrid of two components above. It is extremely difficult to diagnose preoperatively; pathology of surgically resected gross specimen is the most effective means for adequate diagnosis of ASC. Platinum-based postoperative adjuvant chemotherapy for at least four cycles can significantly improve the survival in stage III patients with ASC. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) such as erlotinib and gefitinib can be the effective therapeutic strategies for advanced EGFR-mutant ASC. The studies of crizotinib in the treatment of patients with ASC are very limited. Immune checkpoint blockade therapy may be a potential treatment choice for ASC patients.

Keywords: adenosquamous carcinoma of the lung; chemotherapy; clinicopathological characteristics; histogenesis; immunotherapy; prognosis; targeted therapy.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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