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. 2018 Aug 13:11:211-215.
doi: 10.2147/IJNRD.S171930. eCollection 2018.

Inflammatory milieu in contrast-induced nephropathy: a prospective single-center study

Ashraf O Oweis  1 , Sameeha A Alshelleh  2 , Ammar K Daoud  1 , Mahmoud M Smadi  3 , Karem H Alzoubi  4
Affiliations

Inflammatory milieu in contrast-induced nephropathy: a prospective single-center study

Ashraf O Oweis et al. Int J Nephrol Renovasc Dis. .

Abstract

Background: Acute kidney injury (AKI) caused by contrast exposure is a common problem, which may cause a significant increase in patients in-hospital stay and therefore the cost of treatment. This study was conducted to evaluate the role of inflammation, inflammatory markers in predicting contrast induced nephropathy (CIN). This is a prospective study that was carried out in a major tertiary referral hospital in Jordan.

Methods: Clinical data, blood and urine samples were collected from all patients admitted to the cardiology unit. All patients who agreed to participate in the study had creatinine level analysis 48-72 hours after the procedure. The CIN was defined as an increase in serum creatinine by 25% or 44 μmol/L from the baseline within 48-72 hours after the contrast administration. Patients with stage 4, 5 renal failure, patients on dialysis, and patients with recent intravenous contrast use, active infection or cancer were excluded from the study.

Results: Of the total 202 patients, 30 (14.8%) developed CIN. The incidence rate was 21.1% among females and 12.4% among males. In the multivariate analysis, beside eGFR, diuretics, and alkaline phosphatase, IL-33 was significantly associated with CIN, while the other cytokines did not to show this an association.

Conclusion: Serum level of IL-33 was a significant predictor for development of CIN. Good clinical judgment and high serum levels of IL-33 may stratify patients into low and high risk for CIN.

Keywords: acute kidney injury; cardiac catheterization; contrast; cytokines.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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