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. 2018 Aug 15;10(8):211-220.
doi: 10.4251/wjgo.v10.i8.211.

Pancreatic, periampullary and biliary cancer with liver metastases: Should we consider resection in selected cases?

Rachael Chang Lee  1 , Harsh Kanhere  2 , Markus Trochsler  2 , Vy Broadbridge  1 , Guy Maddern  2 , Timothy J Price  1
Affiliations

Pancreatic, periampullary and biliary cancer with liver metastases: Should we consider resection in selected cases?

Rachael Chang Lee et al. World J Gastrointest Oncol. .

Abstract

Aim: To analyse the safety and efficacy of curative intent surgery in biliary and pancreatic cancer.

Methods: An extensive literature review was performed using MEDLINE, Google Scholar and EMBASE to identify articles regarding hepato-pancreatoduodenectomy or resection of liver metastasis in patients with pancreatic, biliary tract, periampullary and gallbladder cancers.

Results: A total of 19 studies were identified and reviewed. Major hepatectomy was undertaken in 391 patients. The median overall survival for pancreatic cancer ranged from 5-36 mo and for biliary tract/gallbladder cancer, it was 8-38 mo. The 30 d mortality rate was only 1%-9%. Overall Survival was significantly better for patients, who had good response to neoadjuvant chemotherapy, underwent metachronous liver resection and who had intestinal type tumours.

Conclusion: Resection of liver metastases in pancreatic and biliary cancers may provide survival benefit without compromising safety and quality of life in a very select group of patients. These data may be utilised to formulate selection criteria that may allow future investigation of resection in the era of more effective systemic therapy.

Keywords: Cholangiocarcinoma; Gall bladder; Liver resection; Pancreas; Review.

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Conflict of interest statement

Conflict-of-interest statement: All authors have nothing to disclose.

Figures

Figure 1
Figure 1
Literature review.
See this image and copyright information in PMC

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