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Case Reports
. 2018 Jun 19;6(8):1510-1516.
doi: 10.1002/ccr3.1636. eCollection 2018 Aug.

Breast metastasis from EGFR-mutated lung adenocarcinoma: A case report and review of the literature

Takayo Ota  1 , Yoshikazu Hasegawa  1 , Akira Okimura  2 , Katsuya Sakashita  3 , Takeshi Sunami  3 , Kiyotaka Yukimoto  3 , Ryugo Sawada  3 , Kazutsugu Sakamoto  3 , Masahiro Fukuoka  1
Affiliations
Case Reports

Breast metastasis from EGFR-mutated lung adenocarcinoma: A case report and review of the literature

Takayo Ota et al. Clin Case Rep. .

Abstract

Although lung cancer rarely metastasizes to the breast, we report a case of breast metastasis from lung adenocarcinoma harboring an epidermal growth factor receptor mutation. This breast metastasis was initially considered recurrent breast cancer and was later diagnosed based on histopathological and molecular examinations as metastasis from lung cancer.

Keywords: EGFR mutation; breast metastasis; lung adenocarcinoma.

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Figures

Figure 1
Figure 1
A, Left breast showing diffuse erythema swelling. B‐D, CT image obtained with mediastinal window settings. B, Irregular mass and satellite nodules (white arrowhead). B and C, Pleural effusion/thickening. D, Axillary lymph nodes (white arrowhead). E and F, CT images obtained with mediastinal window settings showing thickened bronchovascular bundles, indicating lung cancer aggravation (arrows). G and H, CT images obtained with bone settings showing multiple bone metastases (white arrowheads)
Figure 2
Figure 2
Expression of ER, PR, and HER2 in the breast cancer tissue from surgery and from core needle biopsy. (A, C, E) Breast cancer tissue from surgery (×200); (B, D, F) biopsied breast cancer tissue (×200). (A, B) ER, (B, E) PR, and (C, F) HER2. In the breast cancer tissue from surgery, ER was barely positive, PR was positive, and HER2 was 1+. In the breast cancer tissue from core needle biopsy, ER and PR were negative, and HER2 was 1+
Figure 3
Figure 3
IHC analyses of the breast cancer tissue from surgery, lung cancer tissue from surgery, and breast cancer tissue from core needle biopsy. (A, D, G, J, M, P) Breast cancer tissue from surgery (×200); (B, E, H, K, N, Q); lung cancer tissue from surgery (×200); (C, F, I, L, O, R) breast cancer tissue from the core needle biopsy (×200). (A, B, C) HE, (D, E, G) CK7, (G, H, I) CK20, (J, K, L) GCDFP‐15, (M, N, O) napsin A, and (P, Q, R) TTF‐1. HE; hematoxylin and eosin. As shown in figure, the IHC staining pattern of the breast cancer tissue from core needle biopsy was the same that of the lung cancer tissue from surgery but was not the same as that of the breast cancer tissue from surgery
See this image and copyright information in PMC

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