Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Jun 22;6(8):1557-1560.
doi: 10.1002/ccr3.1662. eCollection 2018 Aug.

Discordance for placental mesenchymal dysplasia in a monochorionic diamniotic twin pregnancy: A case report

Affiliations
Case Reports

Discordance for placental mesenchymal dysplasia in a monochorionic diamniotic twin pregnancy: A case report

Willem Gheysen et al. Clin Case Rep. .

Abstract

Placental mesenchymal dysplasia (PMD) occurs in about 1 in 5000 pregnancies. The differential diagnosis between PMD and partial mole is difficult on ultrasound scan, and karyotyping plays a key role in distinguishing PMD from partial mole. Our report is the first to report on the discordancy for PMD in a monochorionic setting.

Keywords: monochorionic twin pregnancy; placental mesenchymal dysplasia; prenatal ultrasound.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A, 2‐D ultrasound image demonstrating normal and molar aspect of the placenta of twin 1 (left) and twin 2 (right), respectively. B, Placenta after color dye injection showing the absence of vascular anastomoses. Twin 1 has an eccentric cord insertion (1 clamp‐left), whereas twin 2 has a marginal cord insertion (right). C, Macroscopic images demonstrating the normal placental tissue of twin 1 (left) and the cystic enlarged part belonging to twin (right)

References

    1. Nayeri UA, West AB, Grossetta Nardini HK, Copel JA, Sfakianaki AK. Systematic review of sonographic findings of placental mesenchymal dysplasia and subsequent pregnancy outcome. Ultrasound Obstet Gynecol. 2013;41:366‐374. - PubMed
    1. Lewi L, Blickstein I, Van Schoubroeck D, et al. Diagnosis and management of heterokaryotypic monochorionic twins. Am J Med Genet. 2006;140A:272‐275. - PubMed
    1. Morales C, Soler A, Badenas C, et al. Reproductive consequences of genome‐wide paternal uniparental disomy mosaicism: description of two cases with different mechanisms of origin and pregnancy outcomes. Fertil Steril. 2009;92:393. e5‐e9. - PubMed
    1. Surti U, Hill LM, Dunn J, Prosen T, Hoffner L. Twin pregnancy with a chimeric androgenetic and biparental placenta in one twin displaying placental mesenchymal dysplasia phenotype. Prenat Diagn. 2005;25:1048‐1056. - PubMed
    1. Robertson M, Geerts L, de Jong G, Wainwright H. Mesenchymal dysplasia in a monochorionic diamniotic twin pregnancy with review of the differential diagnosis of cystic changes in the placenta. J Ultrasound Med. 2007;26:689‐693. - PubMed

Publication types

LinkOut - more resources