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Comment
. 2018 Jan:2:2.
doi: 10.21037/ncri.2018.01.01. Epub 2018 Jan 17.

Multi-leveled suppression of p53 function by HuR IncRNPs

Jen-Hao Yang  1 , Myriam Gorospe  1
Affiliations
Comment

Multi-leveled suppression of p53 function by HuR IncRNPs

Jen-Hao Yang et al. Noncoding RNA Investig. 2018 Jan.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
HuR lncRNPs suppress p53 function at complementary levels. (A) In the presence of HuR cytoplasm, cytoplasmic HuR-lincRNA-p21 complexes result in rapid degradation of lincRNA-p21 via let-7/RISC. Accordingly, neither the transcriptional repressor complex hnRNPK-lincRNA-p21 nor the transcriptional activator complex p53-lincRNA-p21 forms and the p53 transcriptional program is suppressed. At the same time, HuR-PURPL recruits and sequesters MYBBP1A, resulting in a loss in p53 levels via a reduction in p53 stability. Together, HuR lncRNPs both suppress the transcriptional function of p53 and lower p53 abundance in cells; (B) in the absence of HuR, a stable lincRNA-p21 enables the p53-driven transcriptional activation and repression, while PURPL lacks the factor that sequesters MYBBP1A, allowing it to bind and stabilize p53. Accordingly, reduction or inhibition of HuR can activate p53 signaling by both stabilizing p53 and enhancing the p53-governed transcriptional program. PURPL, p53 upregulated regulator of p53 levels; MYBBP1A, MYB-Binding Protein 1a; p53, 53-kDa protein; HuR, human antigen R; LincRNA-p21, long intergenic noncoding RNA p21.
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Comment on

  • Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer.
    Li XL, Subramanian M, Jones MF, Chaudhary R, Singh DK, Zong X, Gryder B, Sindri S, Mo M, Schetter A, Wen X, Parvathaneni S, Kazandjian D, Jenkins LM, Tang W, Elloumi F, Martindale JL, Huarte M, Zhu Y, Robles AI, Frier SM, Rigo F, Cam M, Ambs S, Sharma S, Harris CC, Dasso M, Prasanth KV, Lal A. Li XL, et al. Cell Rep. 2017 Sep 5;20(10):2408-2423. doi: 10.1016/j.celrep.2017.08.041. Cell Rep. 2017. PMID: 28877474 Free PMC article.

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