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. 2018 Sep 1;23(5):e564-e568.
doi: 10.4317/medoral.22649.

Clinicopathologic and immunohistochemical characterization of 14 cases of angioleiomyomas in oral cavity

J Aitken-Saavedra  1 , K-D da Silva, A-P-N Gomes, A-C-U Vasconcelos, A Etges, T-G Nóbrega, S-B-C Tarquinio
Affiliations

Clinicopathologic and immunohistochemical characterization of 14 cases of angioleiomyomas in oral cavity

J Aitken-Saavedra et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Background: Angioleiomyoma (ALM) is a benign neoplasm that originates from vascular smooth muscle. It is extremely rare in oral cavity. The objective of this study was to evaluate the clinicopathological and immunohistochemical characteristics of all oral angioleiomyomas registered in a Center of Diagnosis of Oral Diseases from 1959 to 2017.

Material and methods: Slides from 14 cases of ALM stained with hematoxylin and eosin (H&E) were analyzed to confirm the diagnosis. Moreover, an immunohistochemical panel with alpha-smooth muscle actin (alpha-SMA), desmin, AE1/AE3, CD68, S-100, and CD34 antibodies was performed to evaluate semi-quantitatively the positive cells.

Results: ALM correspond to 0.08% of all benign oral tumors analyzed during the 57-year period. The mean age of the patients was 45 years with a predilection to males (58%). The most frequently reported site was lips (50%). Microscopic analysis on H&E sections revealed similar pattern in all cases, showing well-circumscribed and encapsulated tumors, characterized by a proliferation of smooth muscle cells and wide vascular spaces of varying sizes. The predominant immuno profiles were: alpha-smooth muscle actin (alpha-SMA) positive (strong immunoreactivity); positive variable pattern for desmin, negative immunoprofile for AE1/AE3, CD68, and S-100. The endothelial cells of vascular spaces were CD34+.

Conclusions: Based on the results, the alpha-SM actin can be elected as a good marker for angioleiomyomas and can help the confirmation of the morphologic diagnosis of this lesion.

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Conflict of interest statement

Conflict of interest statement: None.

Figures

Figure 1
Figure 1
Immunohistochemical characteristics of the oral angioleiomiomas (n = 14). Pelotas, Brazil. A) Positive and strong immunoreaction for alpha- smooth muscle actin antibody showed by neoplastic cells. (IHC, X4). B) Positive and variable immunoreaction for desmin antibody showed by neoplastic cells. (IHC, X4). C) Negative immunoreaction for CD68 antibody showed by neoplastic cells. (IHC, X4). D) Negative immunoreaction for S100 antibody showed by neoplastic cells. (IHC, X4). E) Negative immunoreaction for AE1/AE3 antibody showed by neoplastic cells. (IHC, X4). F) Positive immunoreaction for CD34 antibody showed by the endothelial cells lining the vascular spaces. (IHC, X100).
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