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. 2018 Aug 24;15(9):1836.
doi: 10.3390/ijerph15091836.

Use of Non-Steroidal Anti-Inflammatory Drugs and Associated Gastroprotection in a Cohort of Workers

María Jesús Lallana  1 , Cristina Feja  2 , Isabel Aguilar-Palacio  3 , Sara Malo  4 , María José Rabanaque  5
Affiliations

Use of Non-Steroidal Anti-Inflammatory Drugs and Associated Gastroprotection in a Cohort of Workers

María Jesús Lallana et al. Int J Environ Res Public Health. .

Abstract

Background: This study describes the prevalence of non-steroidal anti-inflammatory drug (NSAID) use, and analyses prescribing patterns of NSAIDs and associated gastroprotection.

Methods: The study population consisted of 5650 workers at the General Motors automobile assembly plant in Zaragoza, Spain. NSAID prescription data for 2014 were obtained from the prescription database of Aragon (Spain). NSAID consumption was determined based on the number of defined daily doses purchased per year. Heavy NSAIDs users were identified using Lorenz curves.

Results: NSAID use in the cohort was high (40.7% of workers, 95% CI 39.4⁻41.9). The prescription of proton pump inhibitors increased with age. Gastrointestinal protection was lacking in some participants who were being treated with drugs associated with a high risk of gastrointestinal bleeding. Heavy NSAID users (defined as those above the 95th percentile of consumption), accounted for 26% of total DDDs, and consumed a greater proportion of coxibs than non-heavy users.

Conclusions: The rate of NSAID consumption in the cohort was high. To reduce the risk of gastrointestinal complications, monitoring and adequate gastroprotection are essential in patients who are prescribed NSAIDs for long periods of time or who are treated concomitantly with drugs that increase the risk of gastrointestinal bleeding.

Keywords: gastrointestinal protection; non-steroidal anti-inflammatory drugs; pharmacoepidemiology.

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Conflict of interest statement

The authors have no relevant affiliations or financial involvements with any organization or entity with a financial interest or financial conflict with the subject matter or materials discussed in the manuscript.

Figures

Figure 1
Figure 1
Lorenz curve of non steroidal anti-inflammatory drugs use in the cohort of workers, 2014.
See this image and copyright information in PMC

References

    1. Utilización de Medicamentos Antiinflamatorios no Esteroideos (AINE) en España Durante el Periodo 2000–2012. [(accessed on 5 May 2018)]; Available online: https://www.aemps.gob.es/medicamentosUsoHumano/observatorio/docs/AINE.pdf.
    1. Warlé-van Herwaarden M.F., Koffeman A.R., Vaklhoff V.E., Jong G.W., Kramers C., Sturkenboom M.C., De Smet P.A.G.M. Time-trends in the prescribing of gastroprotective agents to primary care patients initiating low-dose aspirin or non-steroidal anti-inflammatory drugs: A population-based cohort study. Br. J. Clin. Pharmacol. 2015;80:589–598. doi: 10.1111/bcp.12626. - DOI - PMC - PubMed
    1. Lanza F.L., Chan F.K., Quigley E.M. Guidelines for prevention of NSAID-related ulcer complications. Am. J. Gastroenterol. 2009;104:728–738. doi: 10.1038/ajg.2009.115. - DOI - PubMed
    1. Loza E. AINEs en la práctica clínica: Lo que hay que saber. Inf. Ter. Sist. Nac. Salud. 2011;35:88–95.
    1. Ballina J., Carmona L., Laffon A y Grupo de estudio EPISER Effect of non-steroideal antiinflamatory agents in the general population in Spain. Results of the EPISER study. Rev. Esp. Reumatol. 2002;29:337–342.

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