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. 2018 Aug 25;19(9):2521.
doi: 10.3390/ijms19092521.

Chitosan⁻Carboxymethylcellulose-Based Polyelectrolyte Complexation and Microcapsule Shell Formulation

Jagadish Chandra Roy  1   2   3   4 , Ada Ferri  5 , Stéphane Giraud  6   7 , Guan Jinping  8 , Fabien Salaün  9   10
Affiliations

Chitosan⁻Carboxymethylcellulose-Based Polyelectrolyte Complexation and Microcapsule Shell Formulation

Jagadish Chandra Roy et al. Int J Mol Sci. .

Abstract

Chitosan (CH)⁻carboxymethyl cellulose sodium salt (NaCMC) microcapsules containing paraffin oil were synthesized by complex formation, and crosslinked with glutaraldehyde (GTA). The electrostatic deposition of NaCMC onto the CH-coated paraffin oil emulsion droplets was demonstrated by zeta potential and optical microscopy. The optimal process conditions were identified in terms of pH of the aqueous solution (5.5) and CH/NaCMC mass ratio (1:1). Encapsulation of paraffin oil and microcapsule morphology were analyzed by ATR-FTIR and SEM, respectively. The effect of GTA crosslinking on paraffin oil latent heat was investigated by DSC and combined with the values of encapsulation efficiency and core content, supporting the compact shell formation.

Keywords: carboxymethyl cellulose sodium salt; chitosan; emulsion; microcapsule; polyelectrolyte complex.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Zeta potential values of aqueous chitosan (CH) and carboxymethyl cellulose sodium salt (NaCMC) at different pH. Mean values with 95% confidence interval.
Figure 2
Figure 2
Surface tension of aqueous CH and NaCMC at pH 5.5 and 40 °C. Mean values with 95% confidence interval.
Figure 3
Figure 3
CH-based droplets (Emulsion-1) at different pH.
Figure 4
Figure 4
Mean diameter of CH-based Emulsion-1 at pH from 4.0 to 6.0. Mean values with 95% confidence interval.
Figure 5
Figure 5
Zeta potential values after NaCMC layer formation in Emulsion-2. The blue line indicated the neutral (charge balanced) zone of zeta potential. Mean values with 95% confidence interval.
Figure 6
Figure 6
Mechanism of CH–NaCMC complex and crosslinking shell formation.
Figure 7
Figure 7
ATR-FTIR analysis of pure CH, NaCMC, paraffin oil, and crosslinked microcapsules.
Figure 8
Figure 8
Optical microscopic images of crosslinked microcapsules with GTA. (i) 0.3 g and (ii) 0.6 g GTA per unit gram (g) of total biopolymer; SEM images of crosslinked microcapsules with (iii) 0.3 g GTA and (iv) 0.6 g per unit gram of total biopolymer. “H” indicates the diameter in nanometer unit (nm); the yellow circles indicate the typical spherical microcapsules in the aggregates.
See this image and copyright information in PMC

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