'NOTCHing up' the In Vitro Production of Dendritic Cells

Martin Guilliams¹, Charlotte L Scott²

Affiliations

¹ Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address: martin.guilliams@irc.vib-ugent.be.
² Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Electronic address: charlotte.scott@irc.vib-ugent.be.

PMID: 30150090
DOI: 10.1016/j.it.2018.08.002

Comment

'NOTCHing up' the In Vitro Production of Dendritic Cells

Martin Guilliams et al. Trends Immunol. 2018 Oct.

. 2018 Oct;39(10):765-767.

doi: 10.1016/j.it.2018.08.002. Epub 2018 Aug 24.

Authors

Martin Guilliams¹, Charlotte L Scott²

Affiliations

¹ Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address: martin.guilliams@irc.vib-ugent.be.
² Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Electronic address: charlotte.scott@irc.vib-ugent.be.

PMID: 30150090
DOI: 10.1016/j.it.2018.08.002

Abstract

Two studies show that adding NOTCH ligands to Flt3L cultures increases the yield of cDC1s from mouse and human progenitors. Moreover, these NOTCH-DCs more closely resemble in vivo DCs transcriptionally and functionally. This will be extremely valuable for studying DCs in vitro and for further developing autologous DC-based antitumor vaccinations.

PubMed Disclaimer

Comment on

Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.
Kirkling ME, Cytlak U, Lau CM, Lewis KL, Resteu A, Khodadadi-Jamayran A, Siebel CW, Salmon H, Merad M, Tsirigos A, Collin M, Bigley V, Reizis B. Kirkling ME, et al. Cell Rep. 2018 Jun 19;23(12):3658-3672.e6. doi: 10.1016/j.celrep.2018.05.068. Cell Rep. 2018. PMID: 29925006 Free PMC article.
Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity.
Balan S, Arnold-Schrauf C, Abbas A, Couespel N, Savoret J, Imperatore F, Villani AC, Vu Manh TP, Bhardwaj N, Dalod M. Balan S, et al. Cell Rep. 2018 Aug 14;24(7):1902-1915.e6. doi: 10.1016/j.celrep.2018.07.033. Cell Rep. 2018. PMID: 30110645 Free PMC article.

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

Grants and funding

Wellcome Trust/United Kingdom

LinkOut - more resources

Full Text Sources
- ClinicalKey
- Elsevier Science
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

'NOTCHing up' the In Vitro Production of Dendritic Cells

Affiliations

'NOTCHing up' the In Vitro Production of Dendritic Cells

Authors

Affiliations

Abstract

Comment on

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources