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Meta-Analysis
. 2018 Aug 27;10(9):1172.
doi: 10.3390/nu10091172.

Single Nucleotide Polymorphisms in Vitamin D Receptor Gene Affect Birth Weight and the Risk of Preterm Birth: Results From the "Mamma & Bambino" Cohort and A Meta-Analysis

Martina Barchitta  1 , Andrea Maugeri  2 , Maria Clara La Rosa  3 , Roberta Magnano San Lio  4 , Giuliana Favara  5 , Marco Panella  6 , Antonio Cianci  7 , Antonella Agodi  8
Affiliations
Meta-Analysis

Single Nucleotide Polymorphisms in Vitamin D Receptor Gene Affect Birth Weight and the Risk of Preterm Birth: Results From the "Mamma & Bambino" Cohort and A Meta-Analysis

Martina Barchitta et al. Nutrients. .

Abstract

The effect of vitamin D receptor gene (VDR) polymorphisms on adverse pregnancy outcomes-including preterm birth (PTB), low birth weight and small for gestational age-is currently under debate. We investigated 187 mother-child pairs from the Italian "Mamma & Bambino" cohort to evaluate the association of maternal VDR polymorphisms-BsmI, ApaI, FokI and TaqI-with neonatal anthropometric measures and the risk of PTB. To corroborate our results, we conducted a meta-analysis of observational studies. For the FokI polymorphism, we showed that gestational duration and birth weight decreased with increasing number of A allele (p = 0.040 and p = 0.010, respectively). Compared to the GG and GA genotypes, mothers who carried the AA genotype exhibited higher PTB risk (OR = 12.049; 95% CI = 2.606⁻55.709; p = 0.001) after adjusting for covariates. The meta-analysis confirmed this association under the recessive model (OR = 3.67, 95%CI 1.18⁻11.43), and also pointed out the protective effect of BsmI polymorphism against the risk of PTB under the allelic (A vs. G: OR = 0.74; 95%CI 0.59⁻0.93) and recessive (AA vs. GG + AG: OR = 0.62; 95%CI 0.43⁻0.89) models. Our results suggest the association between some maternal VDR polymorphisms with neonatal anthropometric measures and the risk of PTB.

Keywords: birth cohort; gestational duration; pregnancy; vitamin D.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(A) Genotype Distribution of vitamin D receptor gene (VDR) Polymorphisms and (B) comparison between preterm births (PTB, inner ring) and full-term births (outer ring).
Figure 2
Figure 2
Flow diagram of study selection.
Figure 3
Figure 3
Forest plots of the association between ApaI polymorphism and preterm birth under the (A) allelic, (B) dominant and (C) recessive models.
Figure 3
Figure 3
Forest plots of the association between ApaI polymorphism and preterm birth under the (A) allelic, (B) dominant and (C) recessive models.
Figure 4
Figure 4
Forest plots of the association between BsmI polymorphism and preterm birth under the (A) allelic, (B) dominant and (C) recessive models.
Figure 5
Figure 5
Forest plots of the association between FokI polymorphism and preterm birth under the (A) allelic, (B) dominant and (C) recessive models.
Figure 6
Figure 6
Forest plots of the association between TaqI polymorphism and preterm birth under the (A) allelic, (B) dominant and (C) recessive models.
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