Cancer Risks in Vitiligo Patients: A Nationwide Population-Based Study in Taiwan

doi:10.3390/ijerph15091847

. 2018 Aug 27;15(9):1847.

doi: 10.3390/ijerph15091847.

Cancer Risks in Vitiligo Patients: A Nationwide Population-Based Study in Taiwan

Cheng-Yuan Li^{1

2}, Ying-Xiu Dai^{3

4}, Yi-Ju Chen^{5

6}, Szu-Ying Chu^{7

8}, Tzeng-Ji Chen^{9

10}, Chen-Yi Wu^{11

12}, Chih-Chiang Chen^{13

14}, Ding-Dar Lee^{15

16}, Yun-Ting Chang^{17

18}

Affiliations

¹ Department of Dermatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan. Proteinm@yahoo.com.tw.
² School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. Proteinm@yahoo.com.tw.
³ Department of Dermatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan. daiinxiu@gmail.com.
⁴ School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. daiinxiu@gmail.com.
⁵ School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. yjchenmd@vghtc.gov.tw.
⁶ Department of Dermatology, Taichung Veterans General Hospital, Taichung 40705, Taiwan. yjchenmd@vghtc.gov.tw.
⁷ Department of Dermatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan. sychu2@vghtpe.gov.tw.
⁸ School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. sychu2@vghtpe.gov.tw.
⁹ School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. tjchen@vghtpe.gov.tw.
¹⁰ Department of Family Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan. tjchen@vghtpe.gov.tw.
¹¹ Department of Dermatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan. chenyiok@gmail.com.
¹² Institute of Public Health, National Yang-Ming University, Taipei 11221, Taiwan. chenyiok@gmail.com.
¹³ Department of Dermatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan. docs1.tw@yahoo.com.tw.
¹⁴ School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. docs1.tw@yahoo.com.tw.
¹⁵ Department of Dermatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan. ddlee@vghtpe.gov.tw.
¹⁶ School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. ddlee@vghtpe.gov.tw.
¹⁷ Department of Dermatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan. ytchang@vghtpe.gov.tw.
¹⁸ School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. ytchang@vghtpe.gov.tw.

PMID: 30150564
PMCID: PMC6164767
DOI: 10.3390/ijerph15091847

Cancer Risks in Vitiligo Patients: A Nationwide Population-Based Study in Taiwan

Cheng-Yuan Li et al. Int J Environ Res Public Health. 2018.

. 2018 Aug 27;15(9):1847.

doi: 10.3390/ijerph15091847.

Authors

Affiliations

¹ Department of Dermatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan. Proteinm@yahoo.com.tw.
² School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. Proteinm@yahoo.com.tw.
³ Department of Dermatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan. daiinxiu@gmail.com.
⁴ School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. daiinxiu@gmail.com.
⁵ School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. yjchenmd@vghtc.gov.tw.
⁶ Department of Dermatology, Taichung Veterans General Hospital, Taichung 40705, Taiwan. yjchenmd@vghtc.gov.tw.
⁷ Department of Dermatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan. sychu2@vghtpe.gov.tw.
⁸ School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. sychu2@vghtpe.gov.tw.
⁹ School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. tjchen@vghtpe.gov.tw.
¹⁰ Department of Family Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan. tjchen@vghtpe.gov.tw.
¹¹ Department of Dermatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan. chenyiok@gmail.com.
¹² Institute of Public Health, National Yang-Ming University, Taipei 11221, Taiwan. chenyiok@gmail.com.
¹³ Department of Dermatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan. docs1.tw@yahoo.com.tw.
¹⁴ School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. docs1.tw@yahoo.com.tw.
¹⁵ Department of Dermatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan. ddlee@vghtpe.gov.tw.
¹⁶ School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. ddlee@vghtpe.gov.tw.
¹⁷ Department of Dermatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan. ytchang@vghtpe.gov.tw.
¹⁸ School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan. ytchang@vghtpe.gov.tw.

PMID: 30150564
PMCID: PMC6164767
DOI: 10.3390/ijerph15091847

Abstract

Vitiligo is an autoimmune disease characterized by destruction of melanocytes and associated with other autoimmune disease. Whether the dysregulation of immune system enhances oncogenesis or not remains obscure. Until now, no nationwide population-based study has been conducted regarding this. As such, this paper aims to clarify cancer risk in vitiligo patients. A retrospective nationwide population-based cohort study between 2000 and 2010 was performed based on data from the National Health Insurance Research Database of Taiwan. Standardized incidence ratios (SIRs) of cancers were analyzed. Among the 12,391 vitiligo patients (5364 males and 7027 females) and 48,531.09 person-years of observation, a total of 345 cancers were identified. Significantly increased SIRs were observed for prostate cancer in male patients, thyroid cancer and breast cancer in female patients and bladder cancers in both male and female patients. Unfortunately, the low incidence rate of certain cancers limited the power of our statistical analyses. This study demonstrated the patterns of malignancies in vitiligo patients of Taiwan. Compared with the general population, male patients had higher risks of prostate cancer and female patients had higher risks of thyroid cancer and breast cancer. The risks of bladder cancer were also increased in both male and female patients.

Keywords: Taiwan; bladder cancer; breast cancer; malignancy; prostate cancer; thyroid cancer; vitiligo.

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Conflict of interest statement

The authors declare no conflict of interest.

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Association of Functional Polymorphism in Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene with Vitiligo.
Huraib GB, Al Harthi F, Arfin M, Aljamal A, Alrawi AS, Al-Asmari A. Huraib GB, et al. Biomark Insights. 2020 Jan 31;15:1177271920903038. doi: 10.1177/1177271920903038. eCollection 2020. Biomark Insights. 2020. PMID: 32076368 Free PMC article.
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References

1. Boisseau-Garsaud A.M., Garsaud P., Cales-Quist D., Helenon R., Queneherve C., Claire R.C. Epidemiology of vitiligo in the French West Indies (Isle of Martinique) Int. J. Dermatol. 2000;39:18–20. doi: 10.1046/j.1365-4362.2000.00880.x. - DOI - PubMed
1. Kovacs S.O. Vitiligo. J. Am. Acad. Dermatol. 1998;38:647–666. doi: 10.1016/S0190-9622(98)70194-X. - DOI - PubMed
1. Kang K.Y., Kim H.O., Yoon H.S., Lee J., Lee W.C., Ko H.J., Ju J.H., Cho C.S., Kim H.Y., Park S.H. Incidence of cancer among female patients with systemic lupus erythematosus in Korea. Clin. Rheumatol. 2010;29:381–388. doi: 10.1007/s10067-009-1332-7. - DOI - PubMed
1. Laberge G., Mailloux C.M., Gowan K., Holland P., Bennett D.C., Fain P.R., Spritz R.A. Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo. Pigment Cell Res. 2005;18:300–305. doi: 10.1111/j.1600-0749.2005.00242.x. - DOI - PubMed
1. Adoue D. Autoimmune diseases and cancer in elderly. Rev. Med. Interne. 2008;29:S286–S288. doi: 10.1016/j.revmed.2008.10.006. - DOI - PubMed

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[1] Boisseau-Garsaud A.M., Garsaud P., Cales-Quist D., Helenon R., Queneherve C., Claire R.C. Epidemiology of vitiligo in the French West Indies (Isle of Martinique) Int. J. Dermatol. 2000;39:18–20. doi: 10.1046/j.1365-4362.2000.00880.x. - DOI - PubMed

[2] Boisseau-Garsaud A.M., Garsaud P., Cales-Quist D., Helenon R., Queneherve C., Claire R.C. Epidemiology of vitiligo in the French West Indies (Isle of Martinique) Int. J. Dermatol. 2000;39:18–20. doi: 10.1046/j.1365-4362.2000.00880.x. - DOI - PubMed

[3] Kovacs S.O. Vitiligo. J. Am. Acad. Dermatol. 1998;38:647–666. doi: 10.1016/S0190-9622(98)70194-X. - DOI - PubMed

[4] Kovacs S.O. Vitiligo. J. Am. Acad. Dermatol. 1998;38:647–666. doi: 10.1016/S0190-9622(98)70194-X. - DOI - PubMed

[5] Kang K.Y., Kim H.O., Yoon H.S., Lee J., Lee W.C., Ko H.J., Ju J.H., Cho C.S., Kim H.Y., Park S.H. Incidence of cancer among female patients with systemic lupus erythematosus in Korea. Clin. Rheumatol. 2010;29:381–388. doi: 10.1007/s10067-009-1332-7. - DOI - PubMed

[6] Kang K.Y., Kim H.O., Yoon H.S., Lee J., Lee W.C., Ko H.J., Ju J.H., Cho C.S., Kim H.Y., Park S.H. Incidence of cancer among female patients with systemic lupus erythematosus in Korea. Clin. Rheumatol. 2010;29:381–388. doi: 10.1007/s10067-009-1332-7. - DOI - PubMed

[7] Laberge G., Mailloux C.M., Gowan K., Holland P., Bennett D.C., Fain P.R., Spritz R.A. Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo. Pigment Cell Res. 2005;18:300–305. doi: 10.1111/j.1600-0749.2005.00242.x. - DOI - PubMed

[8] Laberge G., Mailloux C.M., Gowan K., Holland P., Bennett D.C., Fain P.R., Spritz R.A. Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo. Pigment Cell Res. 2005;18:300–305. doi: 10.1111/j.1600-0749.2005.00242.x. - DOI - PubMed

[9] Adoue D. Autoimmune diseases and cancer in elderly. Rev. Med. Interne. 2008;29:S286–S288. doi: 10.1016/j.revmed.2008.10.006. - DOI - PubMed

[10] Adoue D. Autoimmune diseases and cancer in elderly. Rev. Med. Interne. 2008;29:S286–S288. doi: 10.1016/j.revmed.2008.10.006. - DOI - PubMed

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Cancer Risks in Vitiligo Patients: A Nationwide Population-Based Study in Taiwan

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Cancer Risks in Vitiligo Patients: A Nationwide Population-Based Study in Taiwan

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