Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Sep 11;54(73):10336-10339.
doi: 10.1039/c8cc06298f.

Hairpin-fuelled catalytic nanobeacons for amplified microRNA imaging in live cells

Jiaoli Wang  1 , Jin Huang, Ke Quan, Jing Li, Yanan Wu, Qiaomei Wei, Xiaohai Yang, Kemin Wang
Affiliations

Hairpin-fuelled catalytic nanobeacons for amplified microRNA imaging in live cells

Jiaoli Wang et al. Chem Commun (Camb). .

Abstract

Direct imaging of low-abundance RNAs in live cells remains challenging because of the relatively low sensitivity of conventional molecular imaging probes. Here, we introduce hairpin-fuelled catalytic nanobeacons for microRNA (miRNA) imaging in live cells with signal amplification capacity. Compared with the conventional nanobeacons in solution, the catalytic nanobeacons could generate two orders of magnitude higher sensitivity.

PubMed Disclaimer

LinkOut - more resources