Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Nov;9(11):1376-1382.
doi: 10.1111/1759-7714.12842. Epub 2018 Aug 28.

Comparison between computed tomography-guided percutaneous microwave ablation and thoracoscopic lobectomy for stage I non-small cell lung cancer

Yongzheng Wang  1   2 , Bin Liu  1   2 , Pikun Cao  3 , Wujie Wang  1   2 , Wei Wang  1   2 , Haiyang Chang  1   2 , Dong Li  3 , Xiao Li  3 , Xiaogang Zhao  4 , Yuliang Li  1   2
Affiliations

Comparison between computed tomography-guided percutaneous microwave ablation and thoracoscopic lobectomy for stage I non-small cell lung cancer

Yongzheng Wang et al. Thorac Cancer. 2018 Nov.

Abstract

Background: The study was conducted to investigate the effectiveness and cost of computed tomography (CT)-guided percutaneous microwave ablation (MWA) and thoracoscopic lobectomy for stage I non-small cell lung cancer (NSCLC).

Methods: We retrospectively analyzed the data of 46 and 85 patients with stage I NSCLC treated with CT-guided percutaneous MWA or thoracoscopic lobectomy, respectively, at our center from July 2013 to June 2015. Overall survival (OS), disease-free survival (DFS), local control rate, hospital stay, and cost were evaluated. Survival curves were constructed using the Kaplan-Meier method and compared using the log-rank test.

Results: The one and two-year OS rates were 97.82% and 91.30% and 97.65% and 90.59% in the MWA and lobectomy groups, respectively. The one and two-year DFS rates were 95.65% and 76.09% and 95.29% and 75.29%, respectively. No significant differences were observed in log-rank analysis between the groups (P = 0.169). The hospital stays in the MWA and lobectomy groups were 6.62 ± 2.31 and 9.57 ± 3.19 days, respectively. The costs of MWA and lobectomy were US$3274.50 ± US$233.91 and US$4678.87 ± US$155.96, respectively. The differences were all significant (P = 0.003).

Conclusion: MWA and thoracoscopic lobectomy for stage I NSCLC demonstrate similar one and two-year OS and DFS, with no significant differences between the two groups. MWA involved a shorter hospital stay and lower cost, thus should be considered a better option for patients with severe cardiopulmonary comorbidity and patients unwilling to undergo surgery.

Keywords: Disease free survival; microwave ablation; non-small-cell lung cancer; overall survival; surgery.

PubMed Disclaimer

Figures

Figure 1
Figure 1
(a) A 2 cm solitary lesion is observed in the right lung (T1c). (b) The microwave ablation (MWA) probe was inserted into the lesion under computed tomography (CT)‐guidance. (c) Contrast‐enhanced CT one month after MWA demonstrated cavernous formation with fibrotic scar, indicating complete ablation.
Figure 2
Figure 2
Overall survival in the microwave ablation (MWA) and thoracoscopic lobectomy groups.
Figure 3
Figure 3
Disease‐free survival in the microwave ablation (MWA) and thoracoscopic lobectomy groups.
See this image and copyright information in PMC

References

    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet‐Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin 2015; 65: 87–108. - PubMed
    1. Chen W, Zheng R, Zhang S et al Annual report on status of cancer in China, 2010. Chin J Cancer Res 2014; 26: 48–58. - PMC - PubMed
    1. Yang F, Sui X, Chen X et al Sublobar resection versus lobectomy in surgical treatment of elderly patients with early‐stage non‐small cell lung cancer (STEPS): Study protocol for a randomized controlled trial. Trials 2016; 17: 191. - PMC - PubMed
    1. Office of the Surgeon General (US), Office on Smoking and Health (US). The Health Consequences of Active Smoking: A Report of the Surgeon General. Centers for Disease Control and Prevention, Atlanta, GA: 2004. - PubMed
    1. Richards TB, White MC, Caraballo RS. Lung cancer screening with low‐dose computed tomography for primary care providers. Prim Care 2014; 41: 307–30. - PMC - PubMed

Publication types