Can We DAMPen the Cross-Talk between the Lung and Kidney in the ICU?

Affiliations

Comment

Mark L Hepokoski et al. Am J Respir Crit Care Med. 2018.

. 2018 Nov 1;198(9):1220-1222.

doi: 10.1164/rccm.201712-2573RR.

¹ Division of Pulmonary and Critical Care Medicine, University of California San Diego, San Diego, California.

No abstract available

Comment on

Mitochondrial DNA and Toll-Like Receptor-9 Are Associated With Mortality in Critically Ill Patients.
Krychtiuk KA, Ruhittel S, Hohensinner PJ, Koller L, Kaun C, Lenz M, Bauer B, Wutzlhofer L, Draxler DF, Maurer G, Huber K, Wojta J, Heinz G, Niessner A, Speidl WS. Krychtiuk KA, et al. Crit Care Med. 2015 Dec;43(12):2633-41. doi: 10.1097/CCM.0000000000001311. Crit Care Med. 2015. PMID: 26448617
Mitochondrial DNA damage associated molecular patterns in ventilator-associated pneumonia: Prevention and reversal by intratracheal DNase I.
Simmons JD, Freno DR, Muscat CA, Obiako B, Lee YL, Pastukh VM, Brevard SB, Gillespie MN. Simmons JD, et al. J Trauma Acute Care Surg. 2017 Jan;82(1):120-125. doi: 10.1097/TA.0000000000001269. J Trauma Acute Care Surg. 2017. PMID: 27787436 Free PMC article.
Impact of Acute Kidney Injury in Patients Hospitalized With Pneumonia.
Chawla LS, Amdur RL, Faselis C, Li P, Kimmel PL, Palant CE. Chawla LS, et al. Crit Care Med. 2017 Apr;45(4):600-606. doi: 10.1097/CCM.0000000000002245. Crit Care Med. 2017. PMID: 28291091

1. Chawla LS, Amdur RL, Faselis C, Li P, Kimmel PL, Palant CE. Impact of acute kidney injury in patients hospitalized with pneumonia. Crit Care Med. 2017;45:600–606. - PubMed
1. Hepokoski M, Englert JA, Baron RM, Crotty-Alexander LE, Fuster MM, Beitler JR, et al. Ventilator-induced lung injury increases expression of endothelial inflammatory mediators in the kidney. Am J Physiol Renal Physiol. 2017;312:F654–F660. - PMC - PubMed
1. Husain-Syed F, Slutsky AS, Ronco C. Lung-kidney cross-talk in the critically ill patient. Am J Respir Crit Care Med. 2016;194:402–414. - PubMed
1. Polverino F, Laucho-Contreras ME, Petersen H, Bijol V, Sholl LM, Choi ME, et al. A pilot study linking endothelial injury in lungs and kidneys in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2017;195:1464–1476. - PMC - PubMed
1. Chawla LS, Amdur RL, Shaw AD, Faselis C, Palant CE, Kimmel PL. Association between AKI and long-term renal and cardiovascular outcomes in United States veterans. Clin J Am Soc Nephrol. 2014;9:448–456. - PMC - PubMed