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. 1986 Jun 25;376(2):363-7.
doi: 10.1016/0006-8993(86)90200-3.

Vasoactive intestinal polypeptide increases inositol phospholipid breakdown in the rat superior cervical ganglion

S Audigier, C Barberis, S Jard

Vasoactive intestinal polypeptide increases inositol phospholipid breakdown in the rat superior cervical ganglion

S Audigier et al. Brain Res. .

Abstract

The effects of VIP and of peptides of the VIP family: secretin, glucagon, the porcine histidine isoleucine containing peptide (PHI) and the rat hypothalamic growth hormone-releasing hormone (rhGRF) on the cyclic AMP and inositol phosphate contents of isolated rat superior cervical ganglia were investigated. We demonstrate that VIP is able to provoke a large inositol lipid breakdown by acting directly on ganglionic cells. This observation suggests the presence in rat superior cervical ganglia of a new type of receptors for VIP or for an unidentified peptide structurally related to VIP.

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