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Comparative Study
. 1986 Jul 9;377(2):362-7.
doi: 10.1016/0006-8993(86)90882-6.

Potent depressant action of baclofen on hippocampal epileptiform activity in vitro: possible use in the treatment of epilepsy

N Ogata, T Matsuo, M Inoue
Comparative Study

Potent depressant action of baclofen on hippocampal epileptiform activity in vitro: possible use in the treatment of epilepsy

N Ogata et al. Brain Res. .

Abstract

Effects of baclofen on the cortical electrical paroxysm were examined using slices of the guinea pig hippocampus. A very low concentration of baclofen (10(-8) M) readily suppressed spontaneous epileptiform discharges of CA3 pyramidal cells, whereas synaptic transmission between mossy fibers and CA3 pyramidal cells were not affected even by 10(-4) M of this drug. Such a strikingly selective depressant action of baclofen on the epileptiform activity raises a possibility that this drug may be effective in the treatment of epilepsy.

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