Canine babesiosis: a perspective on clinical complications, biomarkers, and treatment
- PMID: 30155438
- PMCID: PMC6065580
- DOI: 10.2147/VMRR.S60431
Canine babesiosis: a perspective on clinical complications, biomarkers, and treatment
Abstract
Canine babesiosis is a common tick transmitted disease of dogs worldwide. A number of Babesia sp. can infect dogs and the spectrum is increasing as molecular methods are developed to differentiate organisms. Clinical signs are generally attributed to hemolysis caused by the organisms in the erythrocytes but in some animals with some Babesia spp. there can be an immune mediated component to the anemia and/or a severe inflammatory reaction associated. This complicated form of canine babesiosis is associated with high morbidity and mortality. A variety of clinical markers has been investigated to enable clinicians to provide more accurate prognoses and adapt their treatments which vary according to the infecting species. In this review, we discuss the taxonomy, clinical signs, diagnostic imaging, clinical biomarkers, treatment, and prophylaxis of one of the most common and important diseases of dogs worldwide.
Keywords: babesiosis; dog; vector-borne disease.
Conflict of interest statement
Disclosure The authors have no conflicts of interest in this work.
Similar articles
-
A review of canine babesiosis: the European perspective.Parasit Vectors. 2016 Jun 11;9(1):336. doi: 10.1186/s13071-016-1596-0. Parasit Vectors. 2016. PMID: 27289223 Free PMC article. Review.
-
Emergence of Babesia canis in southern England.Parasit Vectors. 2017 May 17;10(1):241. doi: 10.1186/s13071-017-2178-5. Parasit Vectors. 2017. PMID: 28514953 Free PMC article.
-
Development and validation of a multiplex, real-time PCR assay for Babesia rossi and Babesia vogeli.Ticks Tick Borne Dis. 2019 Feb;10(2):421-432. doi: 10.1016/j.ttbdis.2018.12.004. Epub 2018 Dec 14. Ticks Tick Borne Dis. 2019. PMID: 30591405
-
Canine babesiosis among working dogs of organised kennels in India: A comprehensive haematological, biochemical, clinicopathological and molecular epidemiological multiregional study.Prev Vet Med. 2019 Aug 1;169:104696. doi: 10.1016/j.prevetmed.2019.104696. Epub 2019 May 22. Prev Vet Med. 2019. PMID: 31311632 Free PMC article.
-
Babesiosis.Rev Sci Tech. 2015 Aug;34(2):627-39. doi: 10.20506/rst.34.2.2385. Rev Sci Tech. 2015. PMID: 26601462 Review.
Cited by
-
Diagnostic efficacy of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 for early detection of acute kidney injury in dogs with leptospirosis or babesiosis.Vet Res Commun. 2024 Aug;48(4):2813-2818. doi: 10.1007/s11259-024-10416-x. Epub 2024 May 29. Vet Res Commun. 2024. PMID: 38809503
-
Vector-borne and zoonotic diseases of dogs in North-west New South Wales and the Northern Territory, Australia.BMC Vet Res. 2017 Aug 15;13(1):238. doi: 10.1186/s12917-017-1169-2. BMC Vet Res. 2017. PMID: 28810870 Free PMC article.
-
Differences in serum protein electrophoretic pattern in dogs naturally infected with Babesia gibsoni and Babesia canis.Sci Rep. 2020 Nov 3;10(1):18904. doi: 10.1038/s41598-020-75908-7. Sci Rep. 2020. PMID: 33144631 Free PMC article.
-
18S rRNA Gene-Based Piroplasmid PCR: An Assay for Rapid and Precise Molecular Screening of Theileria and Babesia Species in Animals.Acta Parasitol. 2022 Dec;67(4):1697-1707. doi: 10.1007/s11686-022-00625-2. Epub 2022 Sep 30. Acta Parasitol. 2022. PMID: 36178614 Free PMC article.
-
Ticks and Tick-Borne Pathogens in Recreational Greenspaces in North Central Florida, USA.Microorganisms. 2023 Mar 15;11(3):756. doi: 10.3390/microorganisms11030756. Microorganisms. 2023. PMID: 36985329 Free PMC article.
References
-
- Boozer AL, Macintire DK. Canine babesiosis. Vet Clin North Am Small Anim Pract. 2003;33(4):885–904. viii. - PubMed
-
- Babes V. Sur l’hemoglobinurie bacterienne du boeuf [Bacterial hemoglobinuria in cattle] Rend Acad Sci Ser Ser III Vie. 1888;107:692–694. French.
-
- El-Bahnasawy MM, Khalil HH, Morsy TA. Babesiosis in an Egyptian boy acquired from pet dog, and a general review. J Egypt Soc Parasitol. 2011;41(1):99–108. - PubMed
-
- Schnittger L, Rodriguez AE, Florin-Christensen M, Morrison DA. Babesia: a world emerging. Infect Genet Evol. 2012;12(8):1788–1809. - PubMed
-
- Jacobson LS, Clark IA. The pathophysiology of canine babesiosis: new approaches to an old puzzle. J S Afr Vet Assoc. 1994;65(3):134–145. - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Miscellaneous