Leukocyte-Stromal Interactions Within Lymph Nodes

Abstract

Lymph nodes play a crucial role in the formation and initiation of immune responses, allowing lymphocytes to efficiently scan for foreign antigens and serving as rendezvous points for leukocyte-antigen interactions. Here we describe the major stromal subsets found in lymph nodes, including fibroblastic reticular cells, lymphatic endothelial cells, blood endothelial cells, marginal reticular cells, follicular dendritic cells and other poorly defined subsets such as integrin alpha-7+ pericytes. We focus on biomedically relevant interactions with T cells, B cells and dendritic cells, describing pro-survival mechanisms of support for these cells, promotion of their migration and tolerance-inducing mechanisms that help keep the body free of autoimmune-mediated damage.

Keywords: Endothelial cells; FRCs; Fibroblasts; LECs; Lymph nodes; Lymphatic endothelium; Lymphoid fibroblasts; Non-haematopoietic; Podoplanin; Stromal Immunology; Stromal cells.