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. 2019 Oct;13(5):1352-1360.
doi: 10.1007/s11682-018-9939-4.

Smaller subcortical volume in Parkinson patients with rapid eye movement sleep behavior disorder

Sanne Kamps  1 , Odile A van den Heuvel  1   2 , Ysbrand D van der Werf  2 , Henk W Berendse  3 , Daniel Weintraub  4   5 , Chris Vriend  6   7   8
Affiliations

Smaller subcortical volume in Parkinson patients with rapid eye movement sleep behavior disorder

Sanne Kamps et al. Brain Imaging Behav. 2019 Oct.

Abstract

Parkinson disease (PD) patients with rapid eye movement (REM) sleep behavior disorder (RBD) have worse motor symptoms and non-motor symptoms than patients without RBD. The aim of this study was to examine underlying differences in brain structure from a network perspective. Baseline data were obtained from Parkinson's Progression Markers Initiative (PPMI) participants. We divided PD patients and healthy controls (HC) into RBD positive and RBD negative using a cutoff score of ≥5 on the RBD screening questionnaire. HC with probable RBD were excluded. We first carried out a region-of-interest analysis of structural MRIs using voxel-based morphometry to study volumetric differences for the putamen, thalamus and hippocampus in a cross-sectional design. Additionally, an exploratory whole-brain analysis was performed. To study group differences from a network perspective, we then performed a 'seed-based' analysis of structural covariance, using the bilateral dorsal-caudal putamen, mediodorsal thalamus and anterior hippocampus as seed regions. The volume of the right putamen was smaller in PD patients with RBD. RBD symptom severity correlated negatively with volume of the right putamen, left hippocampus and left thalamus. We did not find any differences in structural covariance between PD patients with and without RBD. Presence of RBD and severity of RBD symptoms in PD are associated with smaller volumes of the putamen, thalamus and hippocampus.

Keywords: Parkinson disease; REM sleep behavior disorder; Structural covariance; Voxel-based morphometry.

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Conflict of interest statement

The authors declare that they have no conflict of interest. Odile A. van den Heuvel received a grant from PhotoPharmics, NIH BD2K (U54 EB020403–02, PI: P.M. Thompson) and NIMH (R01 MH113250–01, PI: H.B. Simpson). Ysbrand van der Werf received a grant from PhotoPharmics. Henk W. Berendse received a grant from The Netherlands Organisation for Health Research and Development (ZonMw 836,011,029, PI: E.M.J. Foncke), The Michael J Fox Foundation (Grant ID 12274, PI: A.D. Windhorst), and The Michael J Fox Foundation (Grant ID 12062, PI: A.H. Jacobs). Daniel Weintraub has received research funding or support from Michael J. Fox Foundation for Parkinson’s Research, National Institutes of Health (NINDS), Novartis Pharmaceuticals, Department of Veterans Affairs, Avid Radiopharmaceuticals, Alzheimer’s Disease Cooperative Study, and the International Parkinson and Movement Disorder Society; honoraria for consultancy from Acadia, Anavex Life Sciences, Biogen, Biotie (Acorda), BlackThorn Therapeutics, Bracket, Clintrex LLC, Eisai Inc., Eli Lilly, Jazz Pharma, Lundbeck, Roche, Sunovion, Takeda, UCB, and the CHDI Foundation; license fee payments from the University of Pennsylvania for the QUIP and QUIP-RS; royalties from Wolters Kluweland; and fees for legal consultation for three lawsuits related to medication prescribing in patients with Parkinson’s disease. Chris Vriend received a grant from Amsterdam Neuroscience and Brain foundation Netherlands.

Figures

Fig. 1
Fig. 1
Selected seeds within bilateral hippocampus (a), thalamus (b) and putamen (c) for SC analyses
Fig. 2
Fig. 2
Flow chart depicting inclusion and exclusion of subjects
Fig. 3
Fig. 3. Scatterplots showing negative correlations between RBDSQ and right putamen, left hippocampus and left thalamus.
Grey shade represents the 95% confidence interval. Abbreviations: RBDSQ: REM-sleep Behavior Disorder Screening Questionnaire
See this image and copyright information in PMC

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