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Review
. 2018 Dec;41(12):1303-1308.
doi: 10.1007/s40264-018-0710-y.

Risks of Opioids in ST-Elevation Myocardial Infarction: A Review

Anne Henrieke Tavenier  1 , Renicus Suffridus Hermanides  2 , Jan Paul Ottervanger  2 , Peter Gerrit Johannes Ter Horst  3 , Elvin Kedhi  2 , Adriaan W J van 't Hof  4   5
Affiliations
Review

Risks of Opioids in ST-Elevation Myocardial Infarction: A Review

Anne Henrieke Tavenier et al. Drug Saf. 2018 Dec.

Abstract

Although opioids are recommended and frequently used in the acute phase of ST-elevation myocardial infarction (STEMI), their use is accompanied by serious side effects. In particular, gastrointestinal adverse effects may disturb absorption of essential oral medication like platelet inhibitors. This may cause suboptimal platelet inhibition and increased risk of acute stent thrombosis. Some clinical studies have already demonstrated these negative results. Alternative strategies to optimize platelet inhibition and pain relief in STEMI are being investigated. Clinicians should become more aware of the potential side effects of opioids in STEMI.

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