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. 1986 Jun;5(6):1237-44.
doi: 10.1002/j.1460-2075.1986.tb04352.x.

Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products

R P Harvey, C J Tabin, D A Melton

Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products

R P Harvey et al. EMBO J. 1986 Jun.

Abstract

We have isolated a Xenopus genomic clone (Xhox-1) that contains two homeoboxes, at least one of which is highly conserved in vertebrates. Two transcripts are derived from Xhox-1 and these are present from early in development through swimming tadpole stages. A detailed analysis of one of the genes shows that it is expressed maternally and that transcription from the zygotic genome begins at mid-gastrulation. Examination of exogastrula shows that the expression of these genes does not depend on neural induction. We have determined the DNA sequence of a Xhox-1 cDNA and this allows us to predict the complete sequence of a vertebrate homeobox protein. Synthetic mRNAs made from this cDNA are translated efficiently in Xenopus oocytes where the homeobox protein localizes to the oocyte nucleus.

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References

    1. Cell. 1982 Oct;30(3):675-86 - PubMed
    1. EMBO J. 1985 Nov;4(11):2961-9 - PubMed
    1. Cell. 1985 Nov;43(1):19-28 - PubMed
    1. Cell. 1985 Dec;43(2 Pt 1):483-92 - PubMed
    1. Nature. 1984 Jul 5-11;310(5972):25-31 - PubMed

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