Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Aug 29;25(1):65.
doi: 10.1186/s12929-018-0469-6.

H. pylori infection and extra-gastroduodenal diseases

Feng-Woei Tsay  1   2 , Ping-I Hsu  3
Affiliations
Review

H. pylori infection and extra-gastroduodenal diseases

Feng-Woei Tsay et al. J Biomed Sci. .

Abstract

Helicobacter pylori infection is the principal cause of peptic ulcer disease, gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue lymphoma. Recent studies have shown that it may interfere with many biological processes and determine or influence the occurrence of many diseases outside the stomach. Currently, the role of H. pylori in idiopathic thrombocytopenic purpura and iron deficiency anemia is well documented. Emerging evidence suggests that it may also contribute to vitamin B12 deficiency, insulin resistance, metabolic syndrome, diabetes mellitus and non-alcoholic liver disease. Additionally, it may increase the risk of acute coronary syndrome, cerebrovascular disease, neurodegenerative disease and other miscellaneous disorders. Different pathogenic mechanisms have been hypothesized, including the occurrence of molecular mimicry and the induction of a low-grade inflammation. This review summarizes the results of the most relevant studies on the extra-gastroduodenal manifestations of H. pylori infection.

Keywords: Helicobacter pylori; Idiopathic thrombocytopenic purpura and vitamin B12 deficiency; Iron deficiency anemia.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
The possible mechanism for the association between H. pylori infection and extra-gasroduodenal diseases
See this image and copyright information in PMC

References

    1. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med. 2002;347(15):1175–1186. - PubMed
    1. Graham DY. Helicobacter pylori update: gastric cancer, reliable therapy, and possible benefits. Gastroenterology. 2015;148(4):719–731. - PMC - PubMed
    1. Realdi G, Dore MP, Fastame L. Extradigestive manifestations of helicobacter pylori infection: fact and fiction. Dig Dis Sci. 1999;44(2):229–236. - PubMed
    1. Suzuki H, Franceschi F, Nishizawa T, et al. Extragastric manifestations of helicobacter pylori infection. Helicobacter. 2011;16(Suppl 1):65–69. - PubMed
    1. Banic M, Franceschi F, Babic Z, et al. Extragastric manifestations of helicobacter pylori infection. Helicobacter. 2012;17(Suppl 1):49–55. - PubMed

MeSH terms