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Comment
. 2018 Sep;50(9):1210-1211.
doi: 10.1038/s41588-018-0213-x.

Genetic risks and clinical rewards

Andrew J Schork  1 , M Anthony Schork  2 , Nicholas J Schork  3   4   5   6
Affiliations
Comment

Genetic risks and clinical rewards

Andrew J Schork et al. Nat Genet. 2018 Sep.
No abstract available

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Figures

Figure 1.
Figure 1.
Conditional probability that an individual possesses a risk of coronary artery disease (CAD) at least 3 times as high as the average person (y-axis) given that the individual possesses a GPS score for atrial fibrillation (AFIB) in the percentiles reflected on the x axis. Left panel: the inset numbers give the strength of the genetic correlation between CAD and AFIB. The vertical dashed line is the percentile of the AFIB GPS distribution associated with a 3-fold a greater risk for AFIB. Right panel: same as the left panel except a third disease, type II diabetes (T2D), is included in the calculations in which it is assumed that T2D has genetic correlations of 0.2 and 0.1 with CAD and AFIB, respectively, and that the GPS percentile for T2D for the individual is the same for AFIB (as given on the x-axis). Note that the shift in the curves in right panel simply reflects the information about CAD risk provided by information about risk of diabetes even though it has weak assumed genetic correlations with CAD and AFIB. All calculations assumed multivariate normality of GPS values. The R package ‘condMVNorm’ was used to compute relevant conditional probabilities.(11)
See this image and copyright information in PMC

Comment on

References

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