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Case Reports
. 2018 May-Aug;22(2):260-262.
doi: 10.4103/jomfp.JOMFP_161_17.

Aggressive histologic features do not predict biologic behavior in melanotic neuroectodermal tumor of infancy

Jeffrey S Marschall  1 , George M Kushner  1 , Brian S Shumway  1
Affiliations
Case Reports

Aggressive histologic features do not predict biologic behavior in melanotic neuroectodermal tumor of infancy

Jeffrey S Marschall et al. J Oral Maxillofac Pathol. 2018 May-Aug.

Abstract

While generally benign, occasional aggressive histologic features in the melanotic neuroectodermal tumor of infancy (MNTI) have been used to justify a diagnosis of malignancy; this could lead to overtreatment. We report a case with presumed aggressive histologic features that did not recur following conservative treatment. This adds evidence that histologic features are not predictive of clinical behavior in MNTI.

Keywords: CD99; Ki-67; malignant; melanotic neuroectodermal tumor; necrosis.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
(a) Clinical photograph (b) computed tomography, axial view (c) epitheloid cells with pigment (top), neuroblastic cells (bottom) (H & E, ×200). (d) Mitotic activity (arrows) within neuroblastic cells (H & E, ×400). (e) Necrosis (top) (H&E, ×100); *inset (H&E, ×400)
Figure 2
Figure 2
Immunohistochemical stains showing (a) membranous reactivity for CD99 in the neuroblastic cells (×400) and (b) increased tumor cell reactivity for Ki-67 (×100); approximately 27% overall positivity was noted in the specimen
See this image and copyright information in PMC

References

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