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Review
. 2018 Aug 6:2018:7619298.
doi: 10.1155/2018/7619298. eCollection 2018.

Efficacy and Safety of Endoscopic Intralesional Triamcinolone Injection for Benign Esophageal Strictures

Ya-Wu Zhang  1   2   3 , Feng-Xian Wei  1   2   3 , Xue-Ping Qi  3 , Zhao Liu  4 , Xiao-Dong Xu  1   2   3 , You-Cheng Zhang  1   2   3
Affiliations
Review

Efficacy and Safety of Endoscopic Intralesional Triamcinolone Injection for Benign Esophageal Strictures

Ya-Wu Zhang et al. Gastroenterol Res Pract. .

Abstract

Objectives: To evaluate the efficacy and safety of endoscopic intralesional triamcinolone injection (ITI) for benign esophageal strictures combined with endoscopic dilation (ED).

Methods: Online databases including MEDLINE, EMBASE, the Cochrane Library, and Web of Science were comprehensively searched for prospective randomized control trials (RCTs) between 1966 and March 2018. A meta-analysis was conducted according to the methods recommended by the Cochrane Collaboration.

Results: Six RCTs consisting of 176 patients were selected. Meta-analysis results showed that additional ITI had a significant advantage in terms of stricture rate and required ED sessions. Surgery-related and non-surgery-related strictures showed similar results. Additional ITI was not associated with significantly increased risk of complications.

Conclusions: Our meta-analysis showed that additional ITI therapy was supposed to be effective and safe for benign esophageal strictures as it reduced the stricture rate and required ED sessions. However, more RCTs are necessary to support these findings.

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Figures

Figure 1
Figure 1
Flow chart of trial selection process.
Figure 2
Figure 2
Summary of methodological quality of included studies.
Figure 3
Figure 3
Forest plot of stricture rate between ITI and control.
Figure 4
Figure 4
Forest plot of EBD sessions during follow-up between ITI and control.
Figure 5
Figure 5
Forest plot of dysphagia-free time between ITI and control.
Figure 6
Figure 6
Inverted funnel plot of stricture rate.
See this image and copyright information in PMC

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