Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Aug 6:2018:7619298.
doi: 10.1155/2018/7619298. eCollection 2018.

Efficacy and Safety of Endoscopic Intralesional Triamcinolone Injection for Benign Esophageal Strictures

Ya-Wu Zhang  1   2   3 , Feng-Xian Wei  1   2   3 , Xue-Ping Qi  3 , Zhao Liu  4 , Xiao-Dong Xu  1   2   3 , You-Cheng Zhang  1   2   3
Affiliations
Review

Efficacy and Safety of Endoscopic Intralesional Triamcinolone Injection for Benign Esophageal Strictures

Ya-Wu Zhang et al. Gastroenterol Res Pract. .

Abstract

Objectives: To evaluate the efficacy and safety of endoscopic intralesional triamcinolone injection (ITI) for benign esophageal strictures combined with endoscopic dilation (ED).

Methods: Online databases including MEDLINE, EMBASE, the Cochrane Library, and Web of Science were comprehensively searched for prospective randomized control trials (RCTs) between 1966 and March 2018. A meta-analysis was conducted according to the methods recommended by the Cochrane Collaboration.

Results: Six RCTs consisting of 176 patients were selected. Meta-analysis results showed that additional ITI had a significant advantage in terms of stricture rate and required ED sessions. Surgery-related and non-surgery-related strictures showed similar results. Additional ITI was not associated with significantly increased risk of complications.

Conclusions: Our meta-analysis showed that additional ITI therapy was supposed to be effective and safe for benign esophageal strictures as it reduced the stricture rate and required ED sessions. However, more RCTs are necessary to support these findings.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow chart of trial selection process.
Figure 2
Figure 2
Summary of methodological quality of included studies.
Figure 3
Figure 3
Forest plot of stricture rate between ITI and control.
Figure 4
Figure 4
Forest plot of EBD sessions during follow-up between ITI and control.
Figure 5
Figure 5
Forest plot of dysphagia-free time between ITI and control.
Figure 6
Figure 6
Inverted funnel plot of stricture rate.
See this image and copyright information in PMC

References

    1. Kim J. H., Shin J. H., Song H. Y. Benign strictures of the esophagus and gastric outlet: interventional management. Korean Journal of Radiology. 2010;11(5):497–506. doi: 10.3348/kjr.2010.11.5.497. - DOI - PMC - PubMed
    1. Siersema P. D., de Wijkerslooth L. R. H. Dilation of refractory benign esophageal strictures. Gastrointestinal Endoscopy. 2009;70(5):1000–1012. doi: 10.1016/j.gie.2009.07.004. - DOI - PubMed
    1. Hashimoto S., Kobayashi M., Takeuchi M., Sato Y., Narisawa R., Aoyagi Y. The efficacy of endoscopic triamcinolone injection for the prevention of esophageal stricture after endoscopic submucosal dissection. Gastrointestinal Endoscopy. 2011;74(6):1389–1393. doi: 10.1016/j.gie.2011.07.070. - DOI - PubMed
    1. Hanaoka N., Ishihara R., Takeuchi Y., et al. Intralesional steroid injection to prevent stricture after endoscopic submucosal dissection for esophageal cancer: a controlled prospective study. Endoscopy. 2012;44(11):1007–1011. doi: 10.1055/s-0032-1310107. - DOI - PubMed
    1. Kottewar S., Siddique S., Uhlich R. M., et al. Sa1543 intra-lesional steroid injections in the treatment of benign recurrent esophageal strictures: a meta-analysis. Gastrointestinal Endoscopy. 2014;79(5, article AB250) doi: 10.1016/j.gie.2014.05.161. - DOI

LinkOut - more resources