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Case Reports
. 2018 Aug 8;2018(1):190-191.
doi: 10.1093/emph/eoy023. eCollection 2018.

Evolutionary mismatch

Melissa B Manus  1   2
Affiliations
Case Reports

Evolutionary mismatch

Melissa B Manus. Evol Med Public Health. .
No abstract available

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Figures

Figure 1.
Figure 1.
The ancestral environment (i) favours a certain combination of alleles (darker colours). Transitions to modernity produce shifts in the allelic combination that is best suited to the new environment (ii-iv). Mismatch occurs when ancestral alleles (star) persist in new settings where the environment, but not yet genetics, has changed.
See this image and copyright information in PMC

References

    1. Corbett S, Courtiol A, Lummaa V. et al. The transition to modernity and chronic disease: mismatch and natural selection. Nat Rev Genetics 2018;19:419–30. - PubMed
    1. Kuzawa CW. The developmental origins of adult health: intergenerational inertia in adaptation and disease In: Trevathan W, Smith EO, McKenna JJ (eds), Evolution and Health. 2008, 325–49. Oxford University Press.
    1. Gluckman PD, Hanson MA.. Living with the past: evolution, development, and patterns of disease. Science 2004;305:1733–6. - PubMed
    1. Neel JV. Diabetes mellitus: a “thrifty” genotype rendered detrimental by “progress”. Am J Hum Genet 1962;14:353–62. - PMC - PubMed
    1. Leonard WR. Lifestyle, diet, and disease: comparative perspectives on the determinants of chronic health risks In:Stearns SC, Koella JC (eds), Evolution in Health and Disease. Oxford University Press, 2010.

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