Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Apr 5:32:29.
doi: 10.14196/mjiri.32.29. eCollection 2018.

Effects of vitamin D optimization on quality of life of patients with fibromyalgia: A randomized controlled trial

Alireza Mirzaei  1 , Mozhdeh Zabihiyeganeh  1 , Seyed Adel Jahed  2 , Elnaz Khiabani  3 , Marzieh Nojomi  4 , Salman Ghaffari  1
Affiliations

Effects of vitamin D optimization on quality of life of patients with fibromyalgia: A randomized controlled trial

Alireza Mirzaei et al. Med J Islam Repub Iran. .

Abstract

Background: Numerous studies have been conducted to evaluate the frequency of hypovitaminosis D in patients with fibromyalgia syndrome (FMS) and its association with FMS symptoms. This study aimed at assessing the effect of hypovitaminosis D on the symptoms and quality of life of patients with fibromyalgia. Methods: A total of 74 FMS patients with hypovitaminosis D were randomly assigned into group A (Trazodone 25 mg at bedtime + vitamin D 50 000 IU weekly) and group B (Trazodone 25 mg at bedtime + placebo). Serum vitamin D level, Widespread Pain Index (WPI), Fibromyalgia Impact Questionnaire (FIQ), Pittsburgh Sleep Quality Index (PSQI), and Short Form Health Survey (SF-36) were used at the beginning of the treatment and 4 and 8 weeks post treatment. Results: Significant improvements were observed in WPI, FIQ, and PSQI scores in both groups. Moreover, combination of vitamin D and Trazodone resulted in significant improvement of SF-36 scores compared to Trazodone therapy. Improvement in pain-related indices including the WPI and the physical component score (PCS) fraction of SF-36 was more noticeable in vitamin D/Trazodone combination therapy. Conclusion: This study suggests that vitamin D supplementation has significant therapeutic benefits in the management of FMS, especially in pain reduction of patients with fibromyalgia. According to our results, a combination of vitamin D supplements and a conventional antidepressant, when given to vitamin D-deficient fibromyalgia patients, could significantly improve both physical and psychological symptoms.

Keywords: Fibromyalgia syndrome; Pain; Quality of life; Vitamin D.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Fig. 2
Fig. 2
See this image and copyright information in PMC

References

    1. Wolfe F. Fibromyalgia. Prognosis in the Rheumatic Diseases: Springer; 1991. p. 321-32.
    1. Wolfe F, Ross K, Anderson J, Russell IJ, Hebert L. The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum. 1995;38(1):19–28. - PubMed
    1. Burckhardt CS, Clark S, Bennett RR. Fibromyalgia and quality of life. J Rheumtol. 1993;20(3):475–9. - PubMed
    1. Armstrong D, Meenagh G, Bickle I, Lee A, Curran E-S, Finch M. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol. 2007;26(4):551–4. - PubMed
    1. Wepner F, Scheuer R, Schuetz-Wieser B, Machacek P, Pieler-Bruha E, Cross HS. et al. Effects of vitamin D on patients with fibromyalgia syndrome: a randomized placebo-controlled trial. PAIN. 2014;155(2):261–8. - PubMed

LinkOut - more resources