The Expanding Role of Systemic Therapy in the Management of Hepatocellular Carcinoma

doi:10.1155/2018/4763832

Review

. 2018 Aug 7:2018:4763832.

doi: 10.1155/2018/4763832. eCollection 2018.

The Expanding Role of Systemic Therapy in the Management of Hepatocellular Carcinoma

Omar Abdel-Rahman^{1

2}, Winson Y Cheung²

Affiliations

¹ Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
² Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, Alberta, Canada.

PMID: 30159302
PMCID: PMC6106970
DOI: 10.1155/2018/4763832

Review

The Expanding Role of Systemic Therapy in the Management of Hepatocellular Carcinoma

Omar Abdel-Rahman et al. Can J Gastroenterol Hepatol. 2018.

. 2018 Aug 7:2018:4763832.

doi: 10.1155/2018/4763832. eCollection 2018.

Authors

Omar Abdel-Rahman^{1

2}, Winson Y Cheung²

Affiliations

¹ Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
² Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, Alberta, Canada.

PMID: 30159302
PMCID: PMC6106970
DOI: 10.1155/2018/4763832

Abstract

Hepatocellular carcinoma (HCC) represents a global health problem, with the majority of patients presenting at an advanced or incurable stage. The development of effective systemic therapy options for this disease has been challenging because many HCC patients suffer from underlying liver cirrhosis that precludes the safe delivery of systemic therapy. The current review seeks to provide an overview of the current systemic therapeutic approaches for advanced HCC as well as some of the novel management strategies that are currently being evaluated.

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References

1. Ferlay J., Soerjomataram I., Dikshit R., et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. 2014;136(5):E359–E386. doi: 10.1002/ijc.29210. - DOI - PubMed
1. Mittal S., El-Serag H. B. Epidemiology of hepatocellular carcinoma: consider the population. Journal of Clinical Gastroenterology. 2013;47(1):S2–S6. doi: 10.1097/mcg.0b013e3182872f29. - DOI - PMC - PubMed
1. Zhu R. X., Seto W.-K., Lai C.-L., Yuen M.-F. Epidemiology of hepatocellular carcinoma in the Asia-Pacific region. Gut and Liver. 2016;10(3):332–339. doi: 10.5009/gnl15257. - DOI - PMC - PubMed
1. Kansagara D., Papak J., Pasha A. S., et al. Screening for hepatocellular carcinoma in chronic liver disease: a systematic review. Annals of Internal Medicine. 2014;161(4):261–269. doi: 10.7326/M14-0558. - DOI - PubMed
1. Abdel-Rahman O. Systemic therapy for hepatocellular carcinoma (HCC): from bench to bedside. Journal of the Egyptian National Cancer Institute. 2013;25(4):165–171. doi: 10.1016/j.jnci.2013.08.002. - DOI - PubMed

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[1] Ferlay J., Soerjomataram I., Dikshit R., et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. 2014;136(5):E359–E386. doi: 10.1002/ijc.29210. - DOI - PubMed

[2] Ferlay J., Soerjomataram I., Dikshit R., et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. 2014;136(5):E359–E386. doi: 10.1002/ijc.29210. - DOI - PubMed

[3] Mittal S., El-Serag H. B. Epidemiology of hepatocellular carcinoma: consider the population. Journal of Clinical Gastroenterology. 2013;47(1):S2–S6. doi: 10.1097/mcg.0b013e3182872f29. - DOI - PMC - PubMed

[4] Mittal S., El-Serag H. B. Epidemiology of hepatocellular carcinoma: consider the population. Journal of Clinical Gastroenterology. 2013;47(1):S2–S6. doi: 10.1097/mcg.0b013e3182872f29. - DOI - PMC - PubMed

[5] Zhu R. X., Seto W.-K., Lai C.-L., Yuen M.-F. Epidemiology of hepatocellular carcinoma in the Asia-Pacific region. Gut and Liver. 2016;10(3):332–339. doi: 10.5009/gnl15257. - DOI - PMC - PubMed

[6] Zhu R. X., Seto W.-K., Lai C.-L., Yuen M.-F. Epidemiology of hepatocellular carcinoma in the Asia-Pacific region. Gut and Liver. 2016;10(3):332–339. doi: 10.5009/gnl15257. - DOI - PMC - PubMed

[7] Kansagara D., Papak J., Pasha A. S., et al. Screening for hepatocellular carcinoma in chronic liver disease: a systematic review. Annals of Internal Medicine. 2014;161(4):261–269. doi: 10.7326/M14-0558. - DOI - PubMed

[8] Kansagara D., Papak J., Pasha A. S., et al. Screening for hepatocellular carcinoma in chronic liver disease: a systematic review. Annals of Internal Medicine. 2014;161(4):261–269. doi: 10.7326/M14-0558. - DOI - PubMed

[9] Abdel-Rahman O. Systemic therapy for hepatocellular carcinoma (HCC): from bench to bedside. Journal of the Egyptian National Cancer Institute. 2013;25(4):165–171. doi: 10.1016/j.jnci.2013.08.002. - DOI - PubMed

[10] Abdel-Rahman O. Systemic therapy for hepatocellular carcinoma (HCC): from bench to bedside. Journal of the Egyptian National Cancer Institute. 2013;25(4):165–171. doi: 10.1016/j.jnci.2013.08.002. - DOI - PubMed

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The Expanding Role of Systemic Therapy in the Management of Hepatocellular Carcinoma

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The Expanding Role of Systemic Therapy in the Management of Hepatocellular Carcinoma

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