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Comment
. 2017 May:1:2.
doi: 10.21037/biotarget.2017.04.01. Epub 2017 May 16.

New insights into MTORC1 amino acid sensing and activation

Damián Gatica  1 , Daniel J Klionsky  1
Affiliations
Comment

New insights into MTORC1 amino acid sensing and activation

Damián Gatica et al. Biotarget. 2017 May.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Comment on

References

    1. Saxton RA, Sabatini DM. mTOR Signaling in Growth, Metabolism, and Disease. Cell 2017;169:361–71. - PubMed
    1. Long X, Lin Y, Ortiz-Vega S, et al. Rheb binds and regulates the mTOR kinase. Curr Biol 2005;15:702–13. - PubMed
    1. Sancak Y, Bar-Peled L, Zoncu R, et al. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010;141:290–303. - PMC - PubMed
    1. Inoki K, Li Y, Xu T, et al. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 2003;17:1829–34. - PMC - PubMed
    1. Sancak Y, Peterson TR, Shaul YD, et al. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 2008;320:1496–501. - PMC - PubMed

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