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. 2019 Jun;80(6):1758-1760.
doi: 10.1016/j.jaad.2018.08.021. Epub 2018 Aug 27.

One in a hundred million: Merkel cell carcinoma in pediatric and young adult patients is rare but more likely to present at advanced stages based on US registry data

Kelly G Paulson  1 , Paul Nghiem  2
Affiliations

One in a hundred million: Merkel cell carcinoma in pediatric and young adult patients is rare but more likely to present at advanced stages based on US registry data

Kelly G Paulson et al. J Am Acad Dermatol. 2019 Jun.
No abstract available

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Figures

Figure 1:
Figure 1:. Incidence Rates of MCC and Melanoma Across the Age Spectrum.
Cases per person-year are shown for the indicated age brackets; crude (unadjusted) incidence rates calculated across the 15 year period from 2001–2015. Note logarithmic scale. Merkel cell carcinoma (ICD-o-3 8247/3; n=27,105 cases) is shown as red circles and invasive melanoma (ICD-O-3 codes 8720–3/3, 8730/3, 8740/3, 8742–6/3, 8760–1/3; n= 975,396 cases) is shown as brown squares.
Figure 2:
Figure 2:. Extent of Disease at Merkel cell carcinoma Diagnosis, by Age.
The fraction of patients presenting with early/late disease is shown as a function of age at diagnosis. Those less than 30 (n=18 persons) are on the left, while those 30 or older are on the right (n=23,666). A significantly higher fraction of pediatric and young adult patients (33%) had distant metastatic disease at diagnosis as compared with older persons (10%; p=0.01).
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