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. 2018 Aug 30;18(1):858.
doi: 10.1186/s12885-018-4759-x.

Using hospital registries in Australia to extend data availability on vulval cancer treatment and survival

David Roder  1 , Margaret Davy  2 , Sid Selva-Nayagam  3 , Sellvakumaram Paramasivam  4 , Jacqui Adams  5 , Dorothy Keefe  6 , Ian Olver  7 , Caroline Miller  8 , Elizabeth Buckley  9 , Kate Powell  10 , Kellie Fusco  9 , Dianne Buranyi-Trevarton  11 , Martin K Oehler  12
Affiliations

Using hospital registries in Australia to extend data availability on vulval cancer treatment and survival

David Roder et al. BMC Cancer. .

Abstract

Background: The value of hospital registries for describing treatment and survival outcomes for vulval cancer was investigated. Hospital registry data from four major public hospitals in 1984-2016 were used because population-based data lacked required treatment and outcomes data. Unlike population registries, the hospital registries had recorded FIGO stage, grade and treatment.

Methods: Unadjusted and adjusted disease-specific survival and multiple logistic regression were used. Disease-specific survivals were explored using Kaplan-Meier product-limit estimates. Hazards ratios (HRs) were obtained from proportional hazards regression for 1984-1999 and 2000-2016. Repeat analyses were undertaken using competing risk regression.

Results: Five-year disease-specific survival was 70%, broadly equivalent to the five-year relative survivals reported for Australia overall (70%), the United Kingdom (70%), USA (72%), Holland (70%), and Germany (Munich) (68%). Unadjusted five-year survival tended to be lower for cancers diagnosed in 2000-2016 than 1984-1999, consistent with survival trends reported for the USA and Canada, but higher for 2000-2016 than 1984-1999 after adjusting for stage and other covariates, although differences were small and did not approach statistical significance (p ≥ 0.40). Surgery was provided as part of the primary course of treatment for 94% of patients and radiotherapy for 26%, whereas chemotherapy was provided for only 6%. Less extensive surgical procedures applied in 2000-2016 than 1984-1999 and the use of chemotherapy increased over these periods. Surgery was more common for early FIGO stages, and radiotherapy for later stages with a peak for stage III. Differences in treatment by surgery and radiotherapy were not found by geographic measures of remoteness and socioeconomic status in adjusted analyses, suggesting equity in service delivery.

Conclusions: The data illustrate the complementary value of hospital-registry data to population-registry data for informing local providers and health administrations of trends in management and outcomes, in this instance for a comparatively rare cancer that is under-represented in trials and under-reported in national statistics. Hospital registries can fill an evidence gap when clinical data are lacking in population-based registries.

Keywords: Vulval cancer stage treatment survival.

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Conflict of interest statement

Ethics approval and consent to participate

Research ethics approval for this study was provided by the South Australian Department of Health and Ageing Human Research Ethics Committee. The SACCR is authorised under Section 64, Part 7 of the South Australian Health Care Act (2008) to support the quality assurance of cancer services.

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

References

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