Addendum: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

David M Howard¹, Mark J Adams², Masoud Shirali², Toni-Kim Clarke², Riccardo E Marioni³, Gail Davies^{3

4}, Jonathan R I Coleman^{5

6}, Clara Alloza², Xueyi Shen², Miruna C Barbu², Eleanor M Wigmore², Jude Gibson², Saskia P Hagenaars^{5

6}, Cathryn M Lewis^{5

6}, Joey Ward⁷, Daniel J Smith⁷, Patrick F Sullivan^{8

9

10}, Chris S Haley¹¹, Gerome Breen^{5

6}, Ian J Deary^{3

4}, Andrew M McIntosh^{2

4}

Affiliations

¹ Division of Psychiatry, University of Edinburgh, EH10 5HF, Edinburgh, UK. D.Howard@ed.ac.uk.
² Division of Psychiatry, University of Edinburgh, EH10 5HF, Edinburgh, UK.
³ Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, EH8 9JZ, Edinburgh, UK.
⁴ Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, UK.
⁵ Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, London, UK.
⁶ NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, SE5 8AF, London, UK.
⁷ Institute of Health and Wellbeing, University of Glasgow, G12 8RZ, Glasgow, UK.
⁸ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden.
⁹ Department of Genetics, University of North Carolina, 27599, Chapel Hill, NC, USA.
¹⁰ Department of Psychiatry, University of North Carolina, 27599, Chapel Hill, NC, USA.
¹¹ Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU, Edinburgh, UK.

David M Howard et al. Nat Commun. 2018.

. 2018 Aug 30;9(1):3578.

doi: 10.1038/s41467-018-05310-5.

¹ Division of Psychiatry, University of Edinburgh, EH10 5HF, Edinburgh, UK. D.Howard@ed.ac.uk.
² Division of Psychiatry, University of Edinburgh, EH10 5HF, Edinburgh, UK.
³ Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, EH8 9JZ, Edinburgh, UK.
⁴ Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, UK.
⁵ Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, London, UK.
⁶ NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, SE5 8AF, London, UK.
⁷ Institute of Health and Wellbeing, University of Glasgow, G12 8RZ, Glasgow, UK.
⁸ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden.
⁹ Department of Genetics, University of North Carolina, 27599, Chapel Hill, NC, USA.
¹⁰ Department of Psychiatry, University of North Carolina, 27599, Chapel Hill, NC, USA.
¹¹ Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU, Edinburgh, UK.

No abstract available

Erratum for

1. Hyde CL, et al. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Nat. Genet. 2016;48:1031–1036. doi: 10.1038/ng.3623. - DOI - PMC - PubMed
1. Bulik-Sullivan KB, et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 2015;47:291–295. doi: 10.1038/ng.3211. - DOI - PMC - PubMed
1. Middeldorp CM, et al. A genome-wide association meta-analysis of attention-deficit/hyperactivity disorder symptoms in population-based paediatric cohorts. J. Am. Acad. Child. Adolesc. Psychiatry. 2016;55:896–905. doi: 10.1016/j.jaac.2016.05.025. - DOI - PMC - PubMed
1. de Leeuw CA, et al. Mooij, J. M., Heskes, T. & Posthuma, D. MAGMA: generalized gene-set analysis of GWAS data. PLoS. Comput. Biol. 2015;11:e1004219. doi: 10.1371/journal.pcbi.1004219. - DOI - PMC - PubMed
1. The Gene Ontology Consortium. Expansion of the gene ontology knowledgebase and resources. Nucleic Acids Res.45, D331–D338 (2017). - PMC - PubMed