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Case Reports
. 2018 Jul-Sep;10(3):166-168.
doi: 10.4103/jgid.jgid_82_17.

Pott Disease in a 14-year-old Girl Affected by Congenital Lamellar Ichthyosis Type 3 and Diabetes Mellitus

Maria Elena Cucuzza  1 , Flavia La Mendola  1 , Angela D'Ambra  1 , Pierluigi Smilari  1 , Filippo Greco  1 , Agata Fiumara  1 , Andrea D Praticò  1   2
Affiliations
Case Reports

Pott Disease in a 14-year-old Girl Affected by Congenital Lamellar Ichthyosis Type 3 and Diabetes Mellitus

Maria Elena Cucuzza et al. J Glob Infect Dis. 2018 Jul-Sep.

Abstract

Extrapulmonary manifestations of tuberculosis (TB) are particularly frequent during childhood, and usually involve the lymph nodes and the skull. They are related to predisposing immunosuppression conditions. A patient affected by diabetes mellitus type 1 (DMT1) and congenital lamellar ichthyosis type 3 came at our attention with a 4-year history of recurrent parotitis and severe back pain and inferior limb hypomobility, which had lasted for 6 months. A diagnosis of chronic TB parotitis combined with Pott disease was performed after a suggestive spinal magnetic resonance imaging, and positive culture and polymerase-chain reaction examination. Surgical aspiration of the fluid collection and a 12-month antitubercular treatment resulted in complete resolution of the symptomatology. This is the first report of a Pott disease in a patient affected by the two co-occurrences of two immunosuppression diseases such as DMT1 and congenital lamellar ichthyosis type 3.

Keywords: Congenital lamellar ichthyosis type 3; Pott disease; diabetes mellitus type 1; extrapulmonary tuberculosis; spinal tuberculosis; tuberculosis.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
T2-weighted spine magnetic resonance imaging, sagittal scan, of the patient at presentation, which allowed the diagnosis of Pott disease. The abscess (yellow arrows), anteriorly located, extends from L5 to S2 and involves the intervertebral disc L5/S1
See this image and copyright information in PMC

References

    1. Devrim I, Aktürk H, Bayram N, Apa H, Tulumoğlu S, Devrim F, et al. Differences between pediatric extra-pulmonary and pulmonary tuberculosis: A warning sign for the future. Mediterr J Hematol Infect Dis. 2014;6:e2014058. - PMC - PubMed
    1. Moon MS. Tuberculosis of spine: Current views in diagnosis and management. Asian Spine J. 2014;8:97–111. - PMC - PubMed
    1. Ohno Y, Nakamichi S, Ohkuni A, Kamiyama N, Naoe A, Tsujimura H, et al. Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation. Proc Natl Acad Sci U S A. 2015;112:7707–12. - PMC - PubMed
    1. Sugiura K, Takeichi T, Tanahashi K, Ito Y, Kosho T, Saida K, et al. Lamellar ichthyosis in a collodion baby caused by CYP4F22 mutations in a non-consanguineous family outside the mediterranean. J Dermatol Sci. 2013;72:193–5. - PubMed
    1. Errami N, Benjelloun A, Tahtah N, Hemmaoui B, Jahidi A, Nakkabi I, et al. Tuberculosis of the parotid gland: Histology surprise. Pan Afr Med J. 2015;20:343. - PMC - PubMed

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