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Comment
. 2018 Aug 16:9:1857.
doi: 10.3389/fmicb.2018.01857. eCollection 2018.

Response: Commentary: Probing Genomic Aspects of the Multi-Host Pathogen Clostridium perfringens Reveals Significant Pangenome Diversity, and a Diverse Array of Virulence Factors

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Comment

Response: Commentary: Probing Genomic Aspects of the Multi-Host Pathogen Clostridium perfringens Reveals Significant Pangenome Diversity, and a Diverse Array of Virulence Factors

Raymond Kiu et al. Front Microbiol. .
No abstract available

Keywords: Clostridial infection; Clostridium perfringens; antimicrobial resistance; exotoxins; genomics; pangenome; pathogen; whole genome sequencing.

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Figures

Figure 1
Figure 1
(A) A BLASTn sequence alignment performed on a local machine that aligns epsilon toxin gene etx (NCBI accession: M95206.1) with PacBio-sequenced NCTC8503 previously assembled genome (ENA accession: SAMEA3879480; contig 5: nucleotide position 51607-52593). Only a point mutation at position 762 is detected with 100% coverage and > 99% sequence identity. (B) Toxin profile of NCTC8503 isolate, performed via sequence similarity search (“best-match” approach) pipeline ABRicate (https://github.com/tseemann/abricate; BLASTn-based tool) that confirmed the presence of etx gene in NCTC8503 genome with 99.90% identity (at 100% coverage).

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References

    1. Baums C. G., Schotte U., Amtsberg G., Goethe R. (2004). Diagnostic multiplex PCR for toxin genotyping of Clostridium perfringens isolates. Vet. Microbiol. 100, 11–16. 10.1016/S0378-1135(03)00126-3 - DOI - PubMed
    1. Bennetts H. W. (1930). Bacillus welchii and bowel lesions. With special reference to a case of coccidiosis. Aust. Vet. J. 6, 153–154.
    1. Camacho C., Coulouris G., Avagyan V., Ma N., Papadopoulos J., Bealer K., et al. . (2009). BLAST+: architecture and applications. BMC Bioinformatics 10:421. 10.1186/1471-2105-10-421 - DOI - PMC - PubMed
    1. Ding W., Baumdicker F., Neher R. A. (2018). panX: pan-genome analysis and exploration. Nucleic Acids Res. 46, e5. 10.1093/nar/gkx977 - DOI - PMC - PubMed
    1. Goh S., Chang B. J., Riley T. V. (2005). Effect of phage infection on toxin production by Clostridium difficile. J. Med. Microbiol. 54(Pt 2), 129–135. 10.1099/jmm.0.45821-0 - DOI - PubMed

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