Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Aug 17;4(8):e00737.
doi: 10.1016/j.heliyon.2018.e00737. eCollection 2018 Aug.

Synthesis and characterization of Zinc/Chitosan-Folic acid complex

Subhani Bandara  1 , Codi-Anne Carnegie  1 , Chevaun Johnson  1 , Feyisayo Akindoju  1 , Ebonee Williams  1 , Julia M Swaby  1 , Aderemi Oki  2 , Laura E Carson  1
Affiliations

Synthesis and characterization of Zinc/Chitosan-Folic acid complex

Subhani Bandara et al. Heliyon. .

Abstract

Therapeutic drug delivery systems using polymeric materials is an emerging field of research. However, the use of certain polymers has gained much-needed attention by the researchers due to their low toxic nature. In recent years, chitosan has gained popularity as a potential biodegradable polymer that can be used as a component in drug delivery systems. In this study, we synthesized a chitosan derivative that is composed of both folic acid and zinc and may serve as a viable component of a drug delivery system. The results of Fourier Transform Infrared Spectroscopy (FTIR), solid-state 13C Nuclear Magnetic Resonance Spectroscopy (NMR) and UV-visible Spectroscopy demonstrated a substantial difference between chitosan and ZnS/Chitosan-Folic acid derivative. The results were also confirmed using Thermogravimetric Analysis (TGA) and Scanning Electron Microscopy/Energy Dispersive X-ray Spectroscopy (SEM-EDS) techniques. The average particle size of the ZnS/Chitosan-Folic acid system was measured to be 463.67 ± 5.76 nm, showing that the product is within the nano-size range.

Keywords: Materials science.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Proposed schematic diagram of the preparation of ZnS/Chitosan-Folic acid.
Fig. 2
Fig. 2
Fourier transform infrared spectra of (A) chitosan (B) ZnS/Chitosan and (C) ZnS/Chitosan-Folic acid.
Fig. 3
Fig. 3
Solid State 13C NMR spectra of chitosan (red), ZnS/Chitosan (orange) and ZnS/Chitosan- Folic acid (purple).
Fig. 4
Fig. 4
UV-Vis absorbance spectra of chitosan (red), ZnS/CS (yellow) and ZnS/CS-FA (purple).
Fig. 5
Fig. 5
Thermogravimetric analyses (TGA) curves of chitosan, ZnS/Chitosan, and ZnS/Chitosan-Folic acid samples.
Fig. 6
Fig. 6
SEM images of (a) Chitosan, (b) ZnS/Chitosan, (c) ZnS/Chitosan-Folic acid.
Fig. 7
Fig. 7
EDS of (a) Chitosan, (b) ZnS/Chitosan, (c) ZnS/Chitosan-Folic acid.
Fig. 8
Fig. 8
ZnS/Chitosan-Folic acid nanoparticles (a) average size and polydispersity index, and (b) Zeta potential.
See this image and copyright information in PMC

References

    1. Al-Adilee K.J., Abass A.K., Taher A.M. Synthesis of some transition metal complexes with new heterocyclic thiazolyl azo dye and their uses as sensitizers in photo reactions. J. Mol. Struct. 2016;1108:378–397.
    1. Bakrudeen H.B., Sugunalakshmi M., Reddy B.S.R. Auto-fluorescent mesoporous ZnO nanospheres for drug delivery Carrier application. Mater. Sci. Eng. C Mater. Biol. Appl. 2015;56:335–340. - PubMed
    1. Bujňáková Z., Dutková E., Kello M., Mojzis J., Balaz M., Balaz P., Shpotyuk O. Mechanochemistry of chitosan-coated zinc sulfide (ZnS) nanocrystals for bio-imaging applications. Nanoscale Res. Lett. 2017;12(1):328. - PMC - PubMed
    1. Bujňáková Z., Dutková E., Zorkovská A., Baláž M., Kováč J., Kello M., Mojžiš J., Briančin J., Baláž P. Mechanochemical synthesis and in vitro studies of chitosan-coated InAs/ZnS mixed nanocrystals. J. Mater. Sci. 2017;52(2):721–735.
    1. Bwatanglang I.B., Mohammad F., Yusof N.A., Abdullah J., Hussein M.Z., Alitheen N.B., Abu N. Folic acid targeted Mn:ZnS quantum dots for theranostic applications of cancer cell imaging and therapy. Int. J. Nanomed. 2016;11:413–428. - PMC - PubMed

LinkOut - more resources