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. 2018 Dec;24(6):730-737.
doi: 10.1007/s13365-018-0669-6. Epub 2018 Aug 30.

Screening for viral nucleic acids in vestibular schwannoma

Aril Løge Håvik  1   2   3 , Ove Bruland  2 , Mads Aarhus  4 , Karl-Henning Kalland  5   6 , Tomasz Stokowy  2   3 , Morten Lund-Johansen  1   7 , Per-Morten Knappskog  8   9
Affiliations

Screening for viral nucleic acids in vestibular schwannoma

Aril Løge Håvik et al. J Neurovirol. 2018 Dec.

Abstract

To investigate if viruses are involved in the pathogenesis of vestibular schwannomas (VS), we have screened biopsies from VS patients using different molecular techniques. Screening for the presence of known viruses using a pan-viral microarray assay (ViroChip) indicated the presence of several viruses including human endogenous retrovirus K (HERV-K) and human herpes virus 2 (HHV2). But with the exception of HERV-K, none of the findings could be verified by other methods. Whole transcriptome sequencing showed only the presence of HERV-K transcripts and whole genome sequencing showed only the presence of Epstein-Barr virus, most likely originating from infiltration of lymphocytes. We therefore conclude that it is less likely that viruses are involved in the pathogenesis of vestibular schwannomas.

Keywords: Human endogenous retrovirus K; Next-generation sequencing; Vestibular schwannoma; Viral etiology; ViroChip; Viruses and cancer.

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