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. 2018 Sep 21;20(18):5644-5647.
doi: 10.1021/acs.orglett.8b02351. Epub 2018 Aug 31.

Nickel-Catalyzed Csp2-Csp3 Bond Formation via C-F Bond Activation

Yee Ann Ho  1 , Matthias Leiendecker  1 , Xiangqian Liu  1 , Chengming Wang  1 , Nurtalya Alandini  1 , Magnus Rueping  1   2
Affiliations

Nickel-Catalyzed Csp2-Csp3 Bond Formation via C-F Bond Activation

Yee Ann Ho et al. Org Lett. .

Abstract

A nickel-catalyzed cross coupling of aryl fluorides via C-F bond activation has been developed. The alkylation method allows selective replacement of aryl fluorides by alkyl groups and enables the synthesis of diverse and otherwise difficult to access scaffolds in good yields.

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