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. 2018 Sep 21;20(18):5592-5596.
doi: 10.1021/acs.orglett.8b02268. Epub 2018 Aug 31.

Copper-Catalyzed Geminal Difunctionalization of Terminal Alkynes by Splitting Sulfonyl Hydrazones into Two Parts

Qi Sun  1 , Linge Li  1 , Liyan Liu  1 , Qianqian Guan  1 , Yu Yang  1 , Zhenggen Zha  1 , Zhiyong Wang  1
Affiliations

Copper-Catalyzed Geminal Difunctionalization of Terminal Alkynes by Splitting Sulfonyl Hydrazones into Two Parts

Qi Sun et al. Org Lett. .

Abstract

A copper(I)-catalyzed geminal difunctionalization of terminal alkynes was developed via a carbene migratory insertion and an addition of a sulfonyl anion to the triple bond at the same time under mild reaction conditions, providing a variety of vinyl sulfones with good yields and excellent stereoselectivities.

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