Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Mar 26;57(4):417-441.
doi: 10.1515/cclm-2018-0380.

Application of NMR metabolomics to search for human disease biomarkers in blood

Zikuan Song  1   2 , Haoyu Wang  1   2 , Xiaotong Yin  1   2 , Pengchi Deng  3 , Wei Jiang  1
Affiliations
Free article
Review

Application of NMR metabolomics to search for human disease biomarkers in blood

Zikuan Song et al. Clin Chem Lab Med. .
Free article

Abstract

Recently, nuclear magnetic resonance spectroscopy (NMR)-based metabolomics analysis and multivariate statistical techniques have been incorporated into a multidisciplinary approach to profile changes in small molecules associated with the onset and progression of human diseases. The purpose of these efforts is to identify unique metabolite biomarkers in a specific human disease so as to (1) accurately predict and diagnose diseases, including separating distinct disease stages; (2) provide insights into underlying pathways in the pathogenesis and progression of the malady and (3) aid in disease treatment and evaluate the efficacy of drugs. In this review we discuss recent developments in the application of NMR-based metabolomics in searching disease biomarkers in human blood samples in the last 5 years.

Keywords: biomarker; blood; metabolomics; nuclear magnetic resonance spectroscopy (NMR).

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Wishart DS. Metabolomics: the principles and potential applications to transplantation. Am J Transplant 2005;5:2814–20.
    1. Stringer KA, McKay RT, Karnovsky A, Quemerais B, Lacy P. Metabolomics and its application to acute lung diseases. Front Immunol 2016;7:44.
    1. Wang M, Wang F, Wang Y, Ma X, Zhao M, Zhao C. Metabonomics study of the therapeutic mechanism of Gynostemma pentaphyllum and atorvastatin for hyperlipidemia in rats. PLoS One 2013;8:e78731.
    1. Chan AW, Mercier P, Schiller D, Bailey R, Robbins S, Eurich DT, et al. (1)H-NMR urinary metabolomic profiling for diagnosis of gastric cancer. Br J Cancer 2016;114:59–62.
    1. Hunter WG, Kelly JP, McGarrah RW, Kraus WE, Shah SH. Metabolic dysfunction in heart failure: diagnostic, prognostic, and pathophysiologic insights from metabolomic profiling. Curr Heart Fail Rep 2016;13:119–31.

LinkOut - more resources