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. 2018 Aug;97(35):e12026.
doi: 10.1097/MD.0000000000012026.

Short-term and long-term outcomes of liver transplantation using moderately and severely steatotic donor livers: A systematic review

Chenjiao Wu  1 , Chao Lu, Chengfu Xu
Affiliations

Short-term and long-term outcomes of liver transplantation using moderately and severely steatotic donor livers: A systematic review

Chenjiao Wu et al. Medicine (Baltimore). 2018 Aug.

Abstract

Background: The aim of this study was to perform a systemic review of the studies addressing the use of moderately and severely steatotic donor livers for liver transplantation.

Methods: We searched the following electronic databases from January 1, 1989, to August 1, 2017: PubMed, EMBASE, Science Citation Index Expanded, and the Cochrane Library. In addition, reference lists were scanned to identify any additional reports. The quality of published papers was assessed. The main outcomes of the use of moderately and severely steatotic donor livers for liver transplantation, including primary nonfunction, short-term mortality, and long-term mortality, were extracted for pooled analysis.

Results: Literature searches identified 16 studies that met the inclusion criteria. There were no randomized controlled studies, and all of the studies were retrospective or prospective case series. From a total of 3226 subjects (532 moderately and severely steatotic donor livers and 2694 controls), we found a significant increase in primary nonfunction [odds ratio (OR): 2.47, 95% confidence interval (95% CI): 1.44-4.27], and a trend of increase in 1-month patient mortality (OR: 1.90, 95% CI: 0.98-3.71) with the use of moderately and severely steatotic donor livers, whereas the 1-year mortality was relatively less influenced.

Conclusion: The use of moderately and severely steatotic livers is associated with unfavorable short-term outcomes, but long-term outcomes are relatively less influenced.

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Conflict of interest statement

The authors have no conflicts of interest.

Figures

Figure 1
Figure 1
Identification of trials for inclusion.
Figure 2
Figure 2
The incidence of PNF was significantly higher in the observation group than in the control group.
Figure 3
Figure 3
There were a trend of increase in the 1-month patient mortality in the observation group compared with the control group.
Figure 4
Figure 4
There were no statistical differences of 1-year patient mortality.
Figure 5
Figure 5
There were no statistical differences of 1-year graft mortality.
See this image and copyright information in PMC

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