Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2018 Aug 31;19(1):164.
doi: 10.1186/s12931-018-0867-z.

Carbon monoxide levels after inhalation from new generation heated tobacco products

Pasquale Caponnetto  1   2 , Marilena Maglia  1   2 , Gaetano Prosperini  3 , Barbara Busà  4 , Riccardo Polosa  5   6   7   8
Affiliations
Randomized Controlled Trial

Carbon monoxide levels after inhalation from new generation heated tobacco products

Pasquale Caponnetto et al. Respir Res. .

Abstract

Heated tobacco products (HTPs) are new tech devices that release nicotine and other volatile compounds into an inhalable aerosol by heating the tobacco. At their operating temperatures, tobacco combustion is unlikely.The aim of this randomized cross-over study was to measure the exposure levels of the combustion marker, carbon monoxide in the exhaled breath (eCO) of subjects after use of two HTPs and to compare these levels with participants' own brand of cigarettes.A total of 12 healthy smokers who reported smoking ≥10 conventional cigarettes per day for at least 5 years took part in the study. Product administration consisted of a first round of 10 puffs, which was followed by an identical second round after a 5 min pause in between rounds. After obtaining a baseline eCO value, this measure was recorded at 5, 10, 15, 30, and 45 min after the first puff of the first round. In contrast to combustible cigarettes, no eCO elevations were observed in the exhaled breath after use of the HTPs under investigation in any of the study participants.

Keywords: Combustion; Exhaled breath carbon monoxide; Heated tobacco products; Tobacco-heating products.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

This study was approved by the local ERB (reference no. 80/A/2017/P0) and subjects gave written informed consent prior to participation in the study.

Consent for publication

"Not applicable"

Competing interests

R. Polosa is full-time employee of the University of Catania, Italy. In relation to his work in the area of tobacco control, RP has received lecture fees and research funding from Pfizer and GlaxoSmithKline, manufacturers of stop smoking medications. He has also received support from The Consumer Advocates for Smoke-free Alternatives (CASAA) for publication and open access costs of one paper. He has also served as a consultant for Pfizer, Global Health Alliance for treatment of tobacco dependence, ECITA (Electronic Cigarette Industry Trade Association, in the UK), Arbi Group Srl., and Health Diplomat (consulting company that delivers solutions to global health problems with special emphasis on harm minimization). Lectures fees from a number of European electronic cigarette industry and trade associations (including FIVAPE in France and FIESEL in Italy) were directly donated to vapers advocacy no-profit organizations. He is also currently involved in the following pro bono activities: scientific advisor for LIAF, Lega Italiana Anti Fumo (Italian acronym for Italian Anti Smoking League) and for The Consumer Advocates for Smoke-free Alternatives (CASAA); Chair of the European Technical Committee for standardization on “Requirements and test methods for emissions of electronic cigarettes” (CEN/TC 437; WG4). GP is full-time employee of the Catania University Hospitals Trust (MCAU Ospedale Cannizzaro, Catania, Italy). BB is full-time employee of the Catania University Hospitals Trust (ARNAS Garibaldi, Catania, Italy). PC and MM are part-time employees of the University of Catania; their research contracts are supported by university grant no. 21040100 of “Ricerca Scientifica Finanziata dall’Ateneo di Catania”. The authors declare that they have no competing interest.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Time trends of eCO levels, separately for each tobacco product use. Time-trends (means ±95% confidence intervals) of exhaled carbon monoxide (eCO) measured at baseline (BL), and at 5, 10, 15, 30 and 45 min after using iQOS (X), GLO (+), and own brand cigarettes (open circle). The model used to produce the repeated measures ANOVA had product and time-point as main effects and it was adjusted by age, sex and baseline measurements. The within-product effect was significant only for own brand cigarette (p < 0.0001). The between-product effect was significantly different for both HTPs compared to own brand cigarette (p < 0.0001), but no different when iQOS was compared to GLO. Shaded area delineates commonly accepted eCO reference ranges for non smokers
See this image and copyright information in PMC

References

    1. U.S. Department of Health and Human Services. How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2010. - PubMed
    1. Rodgman A, Perfetti TA. The chemical components of tobacco and tobacco smoke. Boca Raton (FL): CRC Press, Taylor & Francis Group; 2009.
    1. Polosa R, Rodu B, Caponnetto P, Maglia M, Raciti C. A fresh look at tobacco harm reduction: the case for the electronic cigarette. Harm Reduct J. 2013;10:10–19. doi: 10.1186/1477-7517-10-19. - DOI - PMC - PubMed
    1. Schlotzhauer WS, Chortyk OT. Recent advances in studies on the pyrosynthesis of cigarette smoke constituents. J Anal ApplPyrol. 1987;12:193–222.
    1. Fagerstrom KO, Hughes JR, Rasmussen T, Callas PW. Randomised trial investigating effect of a novel nicotine delivery device (eclipse) and a nicotine oral inhaler on smoking behaviour, nicotine and carbon monoxide exposure, and motivation to quit. Tob Control. 2000;9:327–333. doi: 10.1136/tc.9.3.327. - DOI - PMC - PubMed

Substances

LinkOut - more resources