Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jan;124(1):32-39.
doi: 10.1111/bcpt.13121. Epub 2018 Oct 4.

Porcine cytochrome 2A19 and 2E1

Viktoriia Burkina  1   2 , Martin Krøyer Rasmussen  3 , Yelyzaveta Oliinychenko  4 , Galia Zamaratskaia  1   2
Affiliations
Review

Porcine cytochrome 2A19 and 2E1

Viktoriia Burkina et al. Basic Clin Pharmacol Toxicol. 2019 Jan.

Abstract

Cytochrome P450 (CYP) is a major group of enzymes, which conduct Phase I metabolism. Among commonly used animal models, the pig has been suggested as the most suitable model for investigating drug metabolism in human beings. Moreover, porcine CYP2A19 and CYP2E1 are responsible for the biotransformation of both endogenous and exogenous compounds such as 3-methylindole (skatole), sex hormones and food compounds. However, little is known about the regulation of porcine CYP2A19 and CYP2E1. In this MiniReview, we summarise the current knowledge about the regulation of porcine CYP2A19 and CYP2E1 by environmental, biological and dietary factors. Finally, we reflect on the need for further research, to clarify the interaction between active feed components and the porcine CYP system.

Keywords: bioactive compounds; phase I enzymes; pig; skatole.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Tralau T, Sowada J, Luch A. Insights on the human microbiome and its xenobiotic metabolism: what is known about its effects on human physiology? Expert Opin Drug Metab Toxicol. 2015;11:411‐425. - PubMed
    1. Suzuki S, Satoh T, Yoshino H, Kobayashi E. Impact of warm ischemic time on microsomal P450 isoforms in a porcine model of therapeutic liver resection. Life Sci. 2004;76:39‐46. - PubMed
    1. Burkina V, Rasmussen MK, Pilipenko N, Zamaratskaia G. Comparison of xenobiotic‐metabolising human, porcine, rodent, and piscine cytochrome P450. Toxicology. 2017;375:10‐27. - PubMed
    1. Babol J, Squires EJ, Lundstrom K. Hepatic metabolism of skatole in pigs by cytochrome P4502E1. J Anim Sci. 1998;76:822‐828. - PubMed
    1. Bæk C, Hansen‐Møller J, Friis C, Cornett C, Hansen SH. Identification of selected metabolites of skatole in plasma and urine from pigs. J Agr Food Chem. 1997;45:2332‐2340.

LinkOut - more resources