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Review
. 2018 Nov:111:182-188.
doi: 10.1016/j.cyto.2018.08.025. Epub 2018 Aug 29.

Differential efficacy of biologic treatments targeting the TNF-α/IL-23/IL-17 axis in psoriasis and psoriatic arthritis

Kazuhisa Furue  1 , Takamichi Ito  1 , Masutaka Furue  2
Affiliations
Review

Differential efficacy of biologic treatments targeting the TNF-α/IL-23/IL-17 axis in psoriasis and psoriatic arthritis

Kazuhisa Furue et al. Cytokine. 2018 Nov.

Abstract

Psoriasis and psoriatic arthritis cause significant physical and psychological burdens for afflicted individuals. An accelerated TNF-α/IL-23/IL-17 axis is their major pathomechanism; therefore, anti-TNF-α/IL-23/IL-17 biologics are very effective for the treatment of skin and joint lesions in psoriasis and psoriatic arthritis. Given that the IL-17 signature is more upregulated in the skin than in synovium in psoriatic arthritis, anti-IL-23/IL-17 agents seem to be superior to anti-TNF-α remedies in the treatment of skin lesions. In this review, we focus on the differential efficacy of anti-TNF-α/IL-23/IL-17 biologics in psoriasis and psoriatic arthritis.

Keywords: Biologics, efficacy; Psoriasis; Psoriatic arthritis; TNF-α/IL-23/IL-17 axis.

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